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muromonab-CD3

(Science: chemical) Anti-cD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral t-cell depletion and modulation of the t-cell receptor complex (CD3/ti). This biochemically purified igG immunoglobulin is obtained through the fusion of mouse myeloma cells to lymphocytes from immunised animals to produce hybridomas that secrete specific antibodies to the t3 (CD3) antigens of human t-lymphocytes. It is often used as an immunosuppressive agent in transplantation.

Pharmacological action: immunosuppressive agents.