Mosaicism

Definition

noun

A condition wherein two or more cell populations with different genotypes exist in an organism, derived from a single zygote, as a result of experimental manipulation or to faulty distribution of genetic material during mitosis


Supplement

Non-Mendelian inheritance is a type of biological inheritance wherein the patterns of phenotypes do not accord with those as expected in Mendelian laws on inheritance. It includes extranuclear inheritance, gene conversion, infectious heredity, genomic imprinting, mosaicism, and trinucleotide repeat disorders.

Mosaicism is a form of non-Mendelian inheritance wherein two or more cell populations with different genotypes exist in an organism, derived from a single zygote, as a result of experimental manipulation or to faulty distribution of genetic material during mitosis. For example is the rare condition wherein some cells of the body of a patient have XX chromosomes while other cells have XY chromosomes. Another example is the 46/47 XY/XXY mosaic in which the individual contains two sets of cell populations: (1) a population of cells with the normal 46 number of chromosomes and XY genetic constitution, and (2) a cell population with 47 chromosomes and XXY genetic consititution.


Word origin: mosaic + -ism

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