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Molecular chaperones

molecular chaperones

A family of cellular proteins that mediate the correct assembly or disassembly of other polypeptides, and in some cases their assembly into oligomeric structures, but which are not components of those final structures. It is believed that chaperone proteins assist polypeptides to self-assemble by inhibiting alternative assembly pathways that produce nonfunctional structures. Some classes of molecular chaperones are the nucleoplasmins, the chaperonins, the heat-shock proteins 70, and the heat-shock proteins 90.


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Primary, Secondard & Teriary Structure of Proteins

... the conformation of the protein is determined by different kind of intermolecular bonds between aminoacid residues: mainly hydrogen bonds, but also ... but the vast majority fold properly(either spontanously or assisted by chaperones). You see, an average protein has more than 100 aminoacids, which ...

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by MrMistery
Mon Apr 30, 2007 12:14 pm
 
Forum: Molecular Biology
Topic: Primary, Secondard & Teriary Structure of Proteins
Replies: 9
Views: 4118

The Fiber Disease

... determine the mechanism by which heat shock protein (hsp) 90 and its co-chaperones mediate the maturation of protein kinases. It will also determine ... research is to understand the basic properties of gliadin (high and low molecular weight glutenin subunits that form the wheat gluten and are ...

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by Nadas Moksha
Sun Nov 05, 2006 4:43 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5559955

The Fiber Disease

... Gsp proteins renders difficult the investigation of their roles in the molecular mechanism of outer membrane translocation. Multiple aspects of ... in their amino acid sequences and requires the binding of secretion chaperones. Those Yops that contain this signal are all injected into the ...

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by Skytroll
Tue May 02, 2006 4:47 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5559955

molecular chaperones

can anyone tell me about the origin and functions of molecular chaperones?how do they help in unfolding of proteins?

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by Great
Sat Mar 12, 2005 6:48 pm
 
Forum: Molecular Biology
Topic: molecular chaperones
Replies: 2
Views: 3029

Origins of Molecular Chaperones ?

many proteins will fold themselves naturally without chaperones.. Gently denature them in a tube, remove the denaturing chemical conditions ... they were. It is also todo with them finding the best / most stable favoured molecular configuration. My understanding is that chaperones help protein fold ...

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by DevGrp
Fri Feb 11, 2005 3:26 pm
 
Forum: Molecular Biology
Topic: Origins of Molecular Chaperones ?
Replies: 3
Views: 3820
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