Dictionary » M » Missense mutation

Missense mutation

Definition

noun

A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation.


Supplement

A missense mutation may lead to the synthesis of a protein that is nonfunctional. For instance in sicke-cell disease, the 20th nucleotide of the gene for the beta chain of hemoglobin on chromosome 11 is changed from the codon GAG to GTG so that when translated the 6th amino acid is now a valine in stead of glutamic acid.


Compare: nonsense mutation, silent mutation
See also: point mutation


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Confusion about Missense Mutation

Yes, agree with JackBean, missense mutation will alter the amino acid. If may not alter the amino acid, we call that silent mutation.

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by magicsiew
Sat Jul 02, 2011 12:06 pm
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1763

Confusion about Missense Mutation

missense mutation IMHO means, that the sense of sequenced is changed, thus it should be the second definition. The first one ...

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by JackBean
Sat Jul 02, 2011 8:07 am
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1763

Confusion about Missense Mutation

Textbook says that it may or may not alter the Amino acid sequence of a protein, while the definition on this site is "A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during ...

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by mekovi
Sat Jul 02, 2011 6:25 am
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1763

about a new Genetic Code

... illustration made a bit clearer and I Took your last two words (Point Mutation) and googled it so i read some articles about that point mutation , Missense mutation and Synonymous substitution and these made it very clear .... thnx for the ...

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by truthSeeker
Tue Jun 29, 2010 9:46 pm
 
Forum: Genetics
Topic: about a new Genetic Code
Replies: 13
Views: 7001

protein sequence

... in a way that inhibits/enhances function. Strictly speaking, benign missense mutation do exist. Of course if your professor told you otherwise, I'd stick with his/her story.

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by mith
Tue Dec 11, 2007 9:09 pm
 
Forum: Molecular Biology
Topic: protein sequence
Replies: 6
Views: 3097
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