Dictionary » M » Missense

Missense

Definition

(Of or relating to) A mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation.


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Compare: nonsense

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LOH/somatic inactivation/biallelic inactivation?

... loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations and frame shift deletions" (http://www.biology-online.org/articles/cellular_molecular_aspects_gastric/molecular_mechanisms_gastric_carcinogenesis.html) ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
 
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 1536

Confusion about Missense Mutation

Yes, agree with JackBean, missense mutation will alter the amino acid. If may not alter the amino acid, we call that silent mutation.

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by magicsiew
Sat Jul 02, 2011 12:06 pm
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1769

Confusion about Missense Mutation

missense mutation IMHO means, that the sense of sequenced is changed, thus it should be the second definition. The first one is probably about point mutations in general.

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by JackBean
Sat Jul 02, 2011 8:07 am
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1769

Confusion about Missense Mutation

Textbook says that it may or may not alter the Amino acid sequence of a protein, while the definition on this site is "A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during tran...

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by mekovi
Sat Jul 02, 2011 6:25 am
 
Forum: Genetics
Topic: Confusion about Missense Mutation
Replies: 2
Views: 1769

about a new Genetic Code

... illustration made a bit clearer and I Took your last two words (Point Mutation) and googled it so i read some articles about that point mutation , Missense mutation and Synonymous substitution and these made it very clear .... thnx for the book btw and thnx for your time :) @mith No , I know that ...

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by truthSeeker
Tue Jun 29, 2010 9:46 pm
 
Forum: Genetics
Topic: about a new Genetic Code
Replies: 13
Views: 7033
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