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Mismatch repair

(Science: molecular biology) A dna repair system that detects and replaces wrongly paired, mismatched, bases in newly replicated dna. e. Coli has a mismatch correction enzyme coded for by three genes mutH, mutL and mutS, that is directed to the newly synthesised strand and removes a segment of that strand including the incorrect nucleotide. The gap is then filled by dna polymerase.