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Michaelis-menten constant

Michaelis-Menten constant --> Michaelis constant

(Science: chemistry) The true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction (usually symbolised by Ks), the concentration of the substrate at which half the true maximum velocity of an enzyme-catalyzed reaction is achieved (when velocities are measured under initial rate and steady state conditions).

The ratio of rate constants (k2 _ k3)/k1 in the single-substrate enzyme-catalyzed reaction: E _ S &dblarr; eS &dblarr; E _ products where E represents the free enzyme, S is the substrate, and ES is the central binary complex. The expression for the michaelis constant will be more complex for multisubstrate reactions.

An apparent michaelis constant is a constant determined either under conditions that are not strictly steady state and initial rate or one that varies with the concentration of one or more cosubstrates.

See: michaelis-Menten equation.

Synonym: michaelis-Menten constant.


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gene redundancy?

... in properties (e.g. preference for substrate, speed of reactions, Michaelis constant etc.), so there will be some difference anyway (at east, there will be less of the ...

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by JackBean
Tue Apr 05, 2011 9:11 pm
 
Forum: Genetics
Topic: gene redundancy?
Replies: 3
Views: 2383

Re: Enzymes- Michaelis Constant

Sorry, could you tell me why the change in primary structure can change Km? :?

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by Nicolodn
Sun Sep 12, 2010 1:05 pm
 
Forum: Cell Biology
Topic: Enzymes- Michaelis Constant
Replies: 8
Views: 2770

Enzymes- Michaelis Constant

Would Enzyme in a dog and the same enzyme in a giraffe have the same Michaelis constant? WHY? THanks

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by Nicolodn
Sun Sep 12, 2010 10:13 am
 
Forum: Cell Biology
Topic: Enzymes- Michaelis Constant
Replies: 8
Views: 2770


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