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Mechanism-based inhibitor

mechanism-based inhibitor --> suicide substrate

A competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme.

Synonym: mechanism-based inhibitor.


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Re: Caffeine Coursework

... the surface of cells without activating them (an "antagonist" mechanism of action). Therefore, caffeine acts as a competitive inhibitor. Adenosine is found in every part of the body, because it plays a role in the fundamental ...

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by red.ninja13
Sun Mar 22, 2009 7:39 pm
 
Forum: Human Biology
Topic: Caffeine Coursework
Replies: 3
Views: 864

Noncompetitive inhibition and allosteric inhibition

... to some extent. All "non-competitive" means is that the inhibitor lowers Vmax without changing Km. You can't read much mechanism into it. The notion of competitive, non-competitive, mixed-competitive are all kinetic ...

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by blcr11
Thu Dec 25, 2008 12:17 pm
 
Forum: Molecular Biology
Topic: Noncompetitive inhibition and allosteric inhibition
Replies: 2
Views: 2023

Drugs and HIV Evolution

... hiv drugs) and various anti-retroviral drugs, such as AZT,Protease inhibitor and HAART and its mechanism ,which had been used to prevent HIV infection. She also tells how Hiv became resistant ...

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by loyolite11
Fri Dec 05, 2008 10:38 am
 
Forum: Biology Movies
Topic: Drugs and HIV Evolution
Replies: 0
Views: 758

Why is mixing alcohol with drugs bad?

... this gastrointestinal damage can be avoided by using selective COX-2 inhibitors... but this had it's own problems... e.g. the COX-2 selective ... supplies of glutathione... however, this is a completely different mechanism of action to how alcohol is metabolised by the liver... the liver ...

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by Revenged
Sun Jan 13, 2008 2:21 pm
 
Forum: Human Biology
Topic: Why is mixing alcohol with drugs bad?
Replies: 3
Views: 2735

repair mechanism?

... for purine synthesis at that stage and caffeine acts only as a mild inhibitor and at high concentration. Never have i read that it inhibits the repair mechanism for other mutations as well. so, unless told otherwise, i will continue to drink ...

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by MrMistery
Sat Nov 18, 2006 8:51 am
 
Forum: Genetics
Topic: repair mechanism?
Replies: 8
Views: 1988
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