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Mature mRNA

Definition

noun

The completely processed mRNA molecule in the cell of eukaryotes.


Supplement

A pre-mRNA molecule becomes a mature mRNA molecule after having undergone the following processes:

  • 5' cap addition – the addition of a 5'cap to the front or 5' end of the pre-mRNA molecule at the start of transcription
  • splicing – removal of any introns (non-coding sequences) and the splicing together of exons (protein-coding sequences)
  • editing – in some instances, the nucleotide composition is altered
  • polyadenylation – a poly a tail is added to the free 3' end at the cleavage site

Once these processes are completed the mature mRNA can then be transported from the nucleus into the cytoplasm for protein translation.


See also: pre-mRNA


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Use of cDNA when studying splicing

... where the authors aim to study the association of certain proteins to mRNA in a splicing-dependent manner. Mainly they compared samples containing ... the non-spliced samples. cDNA is, as far as I know, made from mature mRNA which is fully spliced? Could someone please explain this? Thanks

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by nukeman
Wed May 15, 2013 11:33 am
 
Forum: Molecular Biology
Topic: Use of cDNA when studying splicing
Replies: 1
Views: 794

Re: RNA decoy

Therefore the RNA decoy can bind to microRNA, allowing mature mRNA to start the protein synthesis

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by Depo
Sat Dec 24, 2011 1:29 pm
 
Forum: Genetics
Topic: RNA decoy
Replies: 2
Views: 2935

Re: RNA decoy

... tying up that protein with an RNA decoy would cause production of a mature mRNA that contains the exon of interest (because the absence of bound RNA binding protein on ...

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by jonmoulton
Fri Dec 23, 2011 6:06 pm
 
Forum: Genetics
Topic: RNA decoy
Replies: 2
Views: 2935

Re: can protein size be predicted given genome info?

... it -- that is the end of the coding sequence. The ribosome leaves the mRNA and the sequence downstream of the stop is the 3'-UTR. So, you normally ... and # of amino acids are the same thing. Keep in mind too that the mature form of a protein might be digested by a protease to a smaller form ...

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by jonmoulton
Wed Sep 07, 2011 7:07 pm
 
Forum: Genetics
Topic: can protein size be predicted given genome info?
Replies: 8
Views: 8930

probing mRNA and RT-PCR products

... to understand, what happens with the RNA after transcription untill mature mRNA is formed. Do you know it?

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by JackBean
Thu Jun 09, 2011 6:03 am
 
Forum: Molecular Biology
Topic: probing mRNA and RT-PCR products
Replies: 4
Views: 2456
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