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Mast cells

Mast cell

(Science: cell biology, immunology) resident cell of connective tissue that contains many granules rich in histamine and heparan sulphate.

release of histamine from mast cells is responsible for the immediate reddening of the skin in a weal and flare response. Very similar to basophils and possibly derived from the same stem cells.

two types of mast cells are now recognised, those from connective tissue and a distinct set of mucosal mast cells, the activities of the latter are T-cell dependent.


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The Immune System - Recognition in innate immunity. How?

... molecule and relies on clonal expansion (each cell and its daughter cells of a given cell type have similar antigen recognizing receptor and ... capable of binding with high affinity to the surface of basophils and mast cells (Fce receptors). They also have different kind of disulphide bonding ...

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by biohazard
Tue May 12, 2009 7:43 am
 
Forum: Cell Biology
Topic: The Immune System - Recognition in innate immunity. How?
Replies: 1
Views: 1272

Histidine

... 3. Decarboxylation into histamine which is found predominately in mast cells and plays important roles in immune function and as a paracrine agent acting on the stomach. ...

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by jmyhre
Thu Jan 22, 2009 6:10 pm
 
Forum: Physiology
Topic: Histidine
Replies: 0
Views: 828

Gene activation?

... Here are two scenarios: Scenario 1: Gene X cause cells to divide when the protein it codes for is active. If the gene mutates ... cancerous. (An example of this is the c-kit transmembrane protein in mast cells causing mastocytosis). Scenario 2: Gene Y inhibits cell division ...

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by BioLad
Thu Feb 14, 2008 5:30 pm
 
Forum: Genetics
Topic: Gene activation?
Replies: 2
Views: 686

Allergy questions

... digestive means. If it goes into your bloodstream and interacts with mast cells to produce histamine, you'll have your reaction. Antibodies may be produced to neutralize ...

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by mith
Fri Nov 30, 2007 11:29 pm
 
Forum: Human Biology
Topic: Allergy questions
Replies: 18
Views: 2365

Re: An allergy response...

... only refers to type I hypersensitivity i.e. immediate IgE release from mast cells and basophils... e.g. hayfever, peanut allergy... coeliac disease is a cell mediated ...

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by Revenged
Thu Nov 15, 2007 2:38 pm
 
Forum: Human Biology
Topic: Allergy questions
Replies: 18
Views: 2365
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