Malaria

... that can cause it, one from the mother, one from the father. Each gene can be SC or non-SC. If you have two non-SC genes, you are susceptible to malaria (harmful). If you have one SC gene and one non-SC gene, you have protection against malaria (good). If you have two SC genes, you have SC anemia ...

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... genes. There's a good diagram of the gene clusters here . Your second point is also somewhat curious. Fetal hemoglobin actually protects against malaria, it is when that protection is removed as part of the development process, that children become exposed. So the mutation is initially deleterious ...

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... second level at which this argument fails has to do with its relevance to the topic at hand. The fact that a single point mutation confers malaria resistance does not somehow go away because there is another mutation that can mitigate the effects of sickle cell anemia. Your first point ...

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... remind you that it was you who introduced the sickle cell as a beneficial mutation, that NS has (non randomly)selected to protect against against malaria. Actually, I mentioned HIV immunity and antibiotic resistance as examples of beneficial mutations. I brought up sickle cell anemia as an interesting ...

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... remind you that it was you who introduced the sickle cell as a beneficial mutation, that NS has (non randomly)selected to protect against against malaria. So to ensure clarity of the point I raised. It is a fact that fetal hemoglobin protects the unborn child and newborns from the effects of sickle ...

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