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Macrophage

Macrophage

Relatively long lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), kupffer cells of the liver and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa and tumour cells, release substances that stimulate other cells of the immune system and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or langhans giant cells. A large phagocyte; some are fixed and other circulate in the blood stream.A type of white blood cell deriving from monocytes whose primary jobs are to remove wasteful material in the body and to break down red blood cells which are at the end of their life cycle.


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Overexpression

Hi everyone ! I need some help. I would like to overexpress a gene (zfp36) in bone marrow derived-macrophages culture (BMDM). I started my PhD few days ago and I don't have a lot of informations about this technical procedure. So I ask you some questions: - Do you have some ...

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by aureliegineste
Wed Sep 04, 2013 7:48 am
 
Forum: Molecular Biology
Topic: Overexpression
Replies: 2
Views: 1808

Bio Research Paper Writing

... system in senescence (DNA-Damage-Response np). One factor is the loss of the CD28 marker; when CD28 isn’t expressed, antigen-presenting cells like macrophages no longer recognise the T cell and thus aren’t able to alert the immune cell to danger (de Grey 207). Some viruses like HIV are able to ...

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by NathanielZhu
Thu Apr 04, 2013 2:25 am
 
Forum: General Discussion
Topic: Bio Research Paper Writing
Replies: 1
Views: 12643

Nuclei fills the whole cell

... They can uptake GFP proteins from other tissue. People think they might be drosophila kidney, but I dont believe. I think they might be similar to macrophage. Most interestingly, lately I found that, in those cells from the aged adult flies (only from aged fly, but not from young fly), the whole ...

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by genomy
Mon Mar 05, 2012 7:36 pm
 
Forum: Cell Biology
Topic: Nuclei fills the whole cell
Replies: 0
Views: 952

Does Langerhan cell in epidermis change to macrophage?

Langerhans cells are antigen presenting cells and macrophages are phagocytes. They both act in the immune responds. Macrophages are found in the tissue where monocytes(lymphocytes) in the blood, slips it way through into the tissue and differentiate into macrophages. Langerhans cells are found in th...

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by AUY11345303
Tue Dec 20, 2011 3:58 pm
 
Forum: Human Biology
Topic: Does Langerhan cell in epidermis change to macrophage?
Replies: 0
Views: 1235

Can you recommend a vector?

... (as detected by western and qPCR) of the transgene for 8-12 cell passages, but then the CMV becomes silenced. We are working in Raw 267.4 cells, a macrophage line which are apparently notorious for this. So far i am looking for a human promoter within the plasmid which is inducible by the addition ...

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by JimmyTee
Wed Jun 15, 2011 3:17 pm
 
Forum: Molecular Biology
Topic: Can you recommend a vector?
Replies: 0
Views: 1450
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