MYC associated factor X
MYC associated factor X gene is mapped on chromosome 14q23 and a member of the basic helix-loop-helix leucine zipper family of transcription factors where it formed homodimers and heterodimers with other members that complete a common DNA target site to provide a complex system of transcriptional regulation. It has a critical role in DNA replication and acts as a typical tumor suppressor gene.
MYC associated factor X is an oncoprotein implicated in differentiation, proliferation and apoptosis. It is extremely expressed in brain, heart and lung while lower amount in liver, skeletal muscle and kidney. It also undergoes repressed transcription through the recruitment of a chromatin remodeling complex containing H3-Lys-9 histone methyltransferase activity.
MYC associated factor X gene mutation is associated in small cell lung cancer which is mutually exclusive with BRG1 which regulates the expression of MAX through the depletion of BRG1 which strongly hinders cell growth signing an artificial lethal interaction wherein MAX needed BRG1 to activate neuroendocrine transcriptional programs to up-regulate MYC glycolytic related genes. Its mutation is also linked with hereditary pheochromocytoma.
Gene name: MAX
Protein name: Protein max