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Lysosome

Definition

noun, plural: lysosomes

Organelles containing a large range of digestive enzymes used primarily for digestion and removal of excess or worn-out organelles, food particles, and engulfed viruses or bacteria.


Supplement

Their specific functions include digestion of macromolecules from phagocytosis, endocytosis, and autophagy, digestion of bacteria and other waste materials, repair of damage to the plasma membrane by acting as a membrane patch, and apoptosis (e.g. digesting web from the fingers of a 3- to 6-month-old fetus). Often, they are referred to as “suicide-bags” because of their role in autolysis.

Lysosomes were discovered by the Belgian cytologist Christian de Duve in 1949.


Word origin: from the Greek words lysis, which means dissolution or destruction, and soma, which means body.

Related forms: lysosomal (adjective).
Related terms: GERL.


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Results from our forum


Protein endomembrane system

... and contrast the production and pathway of a protein destined to leave the cell with the production and pathway of a protein destined to be in a lysosome. I believe that it is the same until it leaves the Golgi, but I just wanted to check. Please help me. I have a test tomorrow. Thanks. :)

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by danimalswim
Tue Feb 05, 2013 5:23 am
 
Forum: Cell Biology
Topic: Protein endomembrane system
Replies: 1
Views: 1820

Re: Protein expression but no mRNA

... is being endocytosed rather than expressed in the cultured primary cells? I doubt that would be the case because on fusion of the endosome with a lysosome the proteins in the vesicle are usually degraded by the lysosomal enzymes. For the protein to enter using endosomes, it would have to either ...

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by jonmoulton
Wed Feb 22, 2012 4:13 pm
 
Forum: Molecular Biology
Topic: Protein expression but no mRNA
Replies: 10
Views: 5607

Re: MCQ on why lysosomes don't digest themselves

You might want to look into the pH requirements of lysosome enzymes as well and compare the pH of the lysosome with that of the cytoplasm. Of course, to keep these pH's different, the lysosome is separated from the cytoplasm by a strong membrane, ...

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by zombiesagan
Tue Nov 15, 2011 2:59 pm
 
Forum: Cell Biology
Topic: MCQ on why lysosomes don't digest themselves
Replies: 2
Views: 2108

MCQ on why lysosomes don't digest themselves

and how do you think the enzymes distinguish, whether is the material foreign or home-made? I though that lysosome enzymes work inside the cell.

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by JackBean
Tue Nov 15, 2011 6:27 am
 
Forum: Cell Biology
Topic: MCQ on why lysosomes don't digest themselves
Replies: 2
Views: 2108

Viruses and autophagy

... that a virus inserts their genetic material to the host cell which may be incorporated into the host DNA and that autophagy is the fusion of a lysosome and an autophagosome to digest the cell's material. I'm a little confuse on how the process is similar. Can someone help me out? Thanks

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by cookiemonster1
Sat Oct 29, 2011 10:02 pm
 
Forum: Cell Biology
Topic: Viruses and autophagy
Replies: 1
Views: 1017
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