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Lysosome

Definition

noun, plural: lysosomes

Organelles containing a large range of digestive enzymes used primarily for digestion and removal of excess or worn-out organelles, food particles, and engulfed viruses or bacteria.


Supplement

Their specific functions include digestion of macromolecules from phagocytosis, endocytosis, and autophagy, digestion of bacteria and other waste materials, repair of damage to the plasma membrane by acting as a membrane patch, and apoptosis (e.g. digesting web from the fingers of a 3- to 6-month-old fetus). Often, they are referred to as “suicide-bags” because of their role in autolysis.

Lysosomes were discovered by the Belgian cytologist Christian de Duve in 1949.


Word origin: from the Greek words lysis, which means dissolution or destruction, and soma, which means body.

Related forms: lysosomal (adjective).
Related terms: GERL.


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Re: What does "deficient trafficking" means

... the...". Without reading the paper I can't be sure of this. Based on your post, it sounds like the protein if interest is usually sent to the lysosome, but because it is misfolded it is tagged with a ubiquitin which leads to its degradation in the proteosome and its failure to reach the lysosome.

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by jonmoulton
Wed Jul 02, 2014 2:38 pm
 
Forum: Cell Biology
Topic: What does "deficient trafficking" means
Replies: 1
Views: 792

What does "deficient trafficking" means

... mechanism where misfolding of a particular protein leads to its degradation by ubiquitin proteasome pathway and deficient trafficking to the lysosome. What does deficient trafficking means and overall what does this sentence means?? Kindly help me in understanding this.

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by KSJ
Wed Jul 02, 2014 3:10 am
 
Forum: Cell Biology
Topic: What does "deficient trafficking" means
Replies: 1
Views: 792

Protein endomembrane system

... and contrast the production and pathway of a protein destined to leave the cell with the production and pathway of a protein destined to be in a lysosome. I believe that it is the same until it leaves the Golgi, but I just wanted to check. Please help me. I have a test tomorrow. Thanks. :)

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by danimalswim
Tue Feb 05, 2013 5:23 am
 
Forum: Cell Biology
Topic: Protein endomembrane system
Replies: 1
Views: 2321

Re: Protein expression but no mRNA

... is being endocytosed rather than expressed in the cultured primary cells? I doubt that would be the case because on fusion of the endosome with a lysosome the proteins in the vesicle are usually degraded by the lysosomal enzymes. For the protein to enter using endosomes, it would have to either ...

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by jonmoulton
Wed Feb 22, 2012 4:13 pm
 
Forum: Molecular Biology
Topic: Protein expression but no mRNA
Replies: 10
Views: 7100

Re: MCQ on why lysosomes don't digest themselves

You might want to look into the pH requirements of lysosome enzymes as well and compare the pH of the lysosome with that of the cytoplasm. Of course, to keep these pH's different, the lysosome is separated from the cytoplasm by a strong membrane, ...

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by zombiesagan
Tue Nov 15, 2011 2:59 pm
 
Forum: Cell Biology
Topic: MCQ on why lysosomes don't digest themselves
Replies: 2
Views: 2649
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