Lymph Cell

... biohazard. I think i've got it now: The T cells are produced in the thymus as naive CD4+ and CD8+ cells and then recognise the antigen in the lymph nodes (mainly) but recently there have been RTE's discovered which are not yet CD4 or CD8 positive and differentiate upon activation

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... tissues including at the site of infection? Yes, the final stages of lymphocyte differentiation take place in the peripheral tissues. Often this ... Depending on the TCR signaling, prevaling cytokine environment, and cell-cell interactions, the memory cells can be divided to central memory ...

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There are differen stages of differentiation. For CD4+ cells, for example, there are so-called recent thymic emigrants (RTE, yeah sounds ... development. The final adjustment, then, happens in the periphery (such as lymph nodes). Apparently RTEs are a relaively recent finding, with Haines et ...

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So after they have been activated in the lymph nodes they travel to the thymus where they differentiate and then migrate to infected tissue If anyone knows of a source which provides a good overview of this please let me know. I dont want to ...

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Thanks for the quick reply! However there is one thing which is still confusing me, if they differentiate in the lymph then how are the cytokines which favour one differentiation or another delivered. It's just that in my notes it says NK cells and macrophages can have an effect ...

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