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Loss of heterozygosity

Loss of heterozygosity

refers to a mutation that results in the loss of allelic uniqueness, which is often defined as a greater than or equal to 40 percent increase in signal intensity of allelic signal. Loss of heterozygosity is most frequently identified in certain chromosome regions, including 5q, 17p, and 18q.


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Loss of genetic diversity

... algorithm "Consider the equation that describes the expected loss of heterozygosity over t generations from a population whose effective size is Ne: Ht ˆ H0(1 ÿ ...

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by JorgeLobo
Sun Apr 15, 2012 12:44 am
 
Forum: General Discussion
Topic: Loss of genetic diversity
Replies: 8
Views: 5152

LOH/somatic inactivation/biallelic inactivation?

... heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
 
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 1647

p53 mutation help?

i suppose technically you're right - if you wanna be specific loss of heterozygosity means that you would end up with two identical bad alleles, and the only way that ...

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by MrMistery
Mon Apr 12, 2010 11:51 pm
 
Forum: Cell Biology
Topic: p53 mutation help?
Replies: 10
Views: 5004

Re: p53 mutation help?

... insertions etc But in setting he has: iii) You determine that loss of heterozygosity has occurred in the patient’s tumour cells. IMHO it's highly improbable, that ...

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by JackBean
Mon Apr 12, 2010 9:47 am
 
Forum: Cell Biology
Topic: p53 mutation help?
Replies: 10
Views: 5004

p53 mutation help?

... gene to be knocked out? How do I count them? iii) You determine that loss of heterozygosity has occurred in the patient’s tumour cells. List all possible cellular events ...

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by goodyearkl
Sun Apr 11, 2010 3:20 pm
 
Forum: Cell Biology
Topic: p53 mutation help?
Replies: 10
Views: 5004
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