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Lock-and-key model

Definition

noun

A model for enzyme-substrate interaction suggesting that the enzyme and the substrate possess specific complementary geometric shapes that fit exactly into one another. Like a key into a lock, only the correct size and shape of the substrate (the key) would fit into the active site (the key hole) of the enzyme (the lock).


Supplement

The lock and key model theory first postulated by Emil Fischer in 1894 shows the high specificity of enzymes. However, it does not explain the stabilization of the transition state that the enzymes achieve.


Compare: induced fit model.


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Two models of Enzyme-Substrate binding

... merit of the "Induced-fit model" over the "Lock and Key model" regarding enzyme and substrate binding?

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by shobber
Mon Jun 16, 2008 4:47 pm
 
Forum: Molecular Biology
Topic: Two models of Enzyme-Substrate binding
Replies: 2
Views: 5052

Enzyme actions

... Look up enzymes on Wikipedia and it's explained in there. Lock and key model is just that... the substrate fits the active ...

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by Jammerz
Thu Mar 22, 2007 4:13 am
 
Forum: Molecular Biology
Topic: Enzyme actions
Replies: 5
Views: 3506

Enzyme actions

There's also electrical and van de waals forces involved too, the lock and key model ignores all this.

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by mith
Wed Mar 21, 2007 10:23 pm
 
Forum: Human Biology
Topic: Enzyme actions
Replies: 5
Views: 2040

Enzyme actions

... :oops: but I dont know what a 'lock and key model' is (when refering to enzymes). Can anyone ...

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by helpneeded
Tue Mar 20, 2007 1:55 am
 
Forum: Molecular Biology
Topic: Enzyme actions
Replies: 5
Views: 3506

Enzyme actions

... :oops: but I dont know what a 'lock and key model' is (when refering to enzymes). Can anyone ...

See entire post
by helpneeded
Tue Mar 20, 2007 1:43 am
 
Forum: Human Biology
Topic: Enzyme actions
Replies: 5
Views: 2040
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