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Lipoyl dehydrogenase --> dihydrolipoamide dehydrogenase

(Science: enzyme) An enzyme oxidizing dihydrolipoamide at the expense of NAD_; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (e.g., alpha-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation.

Synonym: coenzyme factor, lipoamide dehydrogenase, lipoamide reductase (NADH), lipoyl dehydrogenase.