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Linkages

Linkage

(Science: genetics) tendency for two or more non-allelic genes to be inherited together, because they are located more or less closely on the same chromosome.

thus parental combinations of characters are found more frequently in offspring than nonparental. Linkage is measured by the percentage recombination between loci.


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Re: Any ideas for vaccine development or anti-viral drugs???

... (PMO) transitioning to cell penetrating peptide conjugated PMOs (PPMO) and ending with PMOplus containing a limited number of positively charged linkages in the PMO structure. The initial lead compounds were combinations of two agents targeting separate genes. In the final analysis, a single ...

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by jonmoulton
Mon Sep 15, 2014 3:04 pm
 
Forum: Cell Biology
Topic: Any ideas for vaccine development or anti-viral drugs???
Replies: 2
Views: 479

Re: How did endosymbionts coordinate replication?

... of the mitochondria can be limited by the availability of the nuclear-encoded gene products. It would be interesting if there are faster linkages, such as signaling cascades, the trigger mitochondrial replication checkpoints. I'm speculating; has anyone looked into the literature on this?

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by jonmoulton
Mon Dec 24, 2012 4:24 pm
 
Forum: Cell Biology
Topic: How did endosymbionts coordinate replication?
Replies: 11
Views: 4842

BN-PAGE of purified membrane associated protein

... Your protein is probably aggregating because its being run in a buffer that is making it negatively charged. It may be interacting with the cross linkages of the gel or even binding to itself.

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by daniel.kurz
Fri Nov 18, 2011 4:07 pm
 
Forum: Molecular Biology
Topic: BN-PAGE of purified membrane associated protein
Replies: 7
Views: 2397

Relationship between structure and function of glucoes

... I am do not understand why you said that "starch is a polymer of pure 1-4 β form". I understand that you mean the 1-4 glycosidic linkages are formed from the β form of glucose, but isn't that the α form? And thanks a lot for answering me!

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by Adz795
Tue Sep 13, 2011 5:16 pm
 
Forum: Molecular Biology
Topic: Relationship between structure and function of glucoes
Replies: 12
Views: 17434

Re: Relationship between structure and function of glucoes

... into either the α or β form. Galactose is pure 1-4 α-bound glucose while starch is a polymer of the pure 1-4 β form (though they may also have 1-6 linkages). Now I can look at your question again, Adz. The α and β forms of poly-D-glucose have different mechanical properties and adopt different ...

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by jonmoulton
Tue Sep 13, 2011 3:48 pm
 
Forum: Molecular Biology
Topic: Relationship between structure and function of glucoes
Replies: 12
Views: 17434
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