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Ligands

Ligands

a molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex.


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SELEX

In Systematic evolution of Ligands by Exponential Enrichment a resin column attached with ATP is used for desired ligand development . This ATP give the desire ligand a property for binding tightly with ATP. Should we used any other drug ?

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by Helics
Thu Feb 07, 2013 4:09 pm
 
Forum: Molecular Biology
Topic: SELEX
Replies: 3
Views: 1594

can some one tell what rubp stands for ?

bi- and bis- means the same. Bi- is used for smaller ligands, while bis- is for larger ligands.

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by JackBean
Sat Nov 10, 2012 11:18 am
 
Forum: Molecular Biology
Topic: can some one tell what rubp stands for ?
Replies: 7
Views: 2573

hexokinase conformation

... these don't seem to match the diagrams. I'd like to find pdb structures to illustrate how hexokinase conforms to bind ATP and glucose, with the ligands enclosed inside the molecule. I'd be grateful for any help.

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by andrewJM
Sat Jul 21, 2012 4:45 pm
 
Forum: Molecular Biology
Topic: hexokinase conformation
Replies: 0
Views: 1433

antibiotics vs antibacterial drugs..

... of the body than before. I'm not aware of significant "chemical" synthesis of antibodies - though certainly of associated therapeutic ligands. Can you say more?

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by JorgeLobo
Wed Mar 28, 2012 11:49 am
 
Forum: Microbiology
Topic: antibiotics vs antibacterial drugs..
Replies: 3
Views: 6214

More general biology questions..

1. of course you can use both, but their are kind of complementary. In the first case you have database of millions of possible ligands and try them all on your protein. In the other case, you have structure of your protein and determines the minimum, which binds into it. Then you try ...

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by JackBean
Fri Nov 04, 2011 4:00 pm
 
Forum: Cell Biology
Topic: More general biology questions..
Replies: 1
Views: 5805
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