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Kinase ii

Kinase ii --> peptidyl-dipeptidase a

(Science: enzyme) a hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin i, which is converted to angiotensin ii and histidylleucine.

An important step in the metabolism of certain vasopressor agents.

It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral ph. Only single dipeptides are released from angiotensin i and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.

registry number: EC 3.4.15.1

Synonym: carboxycathepsin, dipeptidyl carboxypeptidase, kinase ii, peptidase P.


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... has two active sites, try to find out something about proof-reading mechanism. I don't know about the ATPase, but I don't remember any mention of kinase or phosphatase.

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by JackBean
Tue Nov 06, 2012 9:23 pm
 
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Although the Sodium Pump is an ATPase, during it's cycle there is a phosphate group being added and taken away from the protein so surely kinase and phosphotase are involved because an ATPase only hydrolyses ATP? Also, we are just going over how Enzymes work with their substrates. Am I right ...

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Re: Kinases

... was the initial ATP and un-phosphorylated protein. That release of energy helps drive the reaction to the ADP & phosphoprotein side. Not every kinase will use ATP as a substrate. Other high-energy phosphates are available in cells and there are many kinases. http://en.wikipedia.org/wiki/Kinase

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