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Isotypes

isotype switching

(Science: immunology) The switch of immunoglobulin isotype that occurs, for example: as the immune response progresses (igm to igg). The switch from igm to igg involves only the constant region of the heavy chains (from _ to _), the light chain and variable regions of the heavy chain remaining the same and involves the switch regions, upstream (on the 5'side) of the constant region genes, at which recombination occurs. Similarly, igm and IgD with the same variable region of the heavy chain, but with different heavy chain constant regions (_ and _), seem to coexist on the surface of some lymphocytes.


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Re: Cytokine - Receptor concepts

... that act in concern with CD40 ( a type of tumor necrosis factor) to stimulate B cell proliferation and production of antibodies of different isotypes. Cytokines serve two principal functions in antibody responses: (1) Provide amplification mechanisms by augmenting B cell proliferation and ...

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by marla
Tue Jun 01, 2010 9:08 pm
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14868

Re: antibody

sorry, yh i did mean isotypes I don't think we can survive with just one class of antibody. Do you mean isotypes? We have 5 isotypes of antibodies. IgA, IgD, IgE, IgG and IgM. Please clarify your question.

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by janekelly
Sun Jan 27, 2008 6:28 pm
 
Forum: Human Biology
Topic: antibody
Replies: 12
Views: 5874

antibody

yup, I think that Jenniferboateng06 refers to those isotypes. Hmm....I can say yes (even though the chance is so little and won't last long), because fetus only have one type of antibody which is IgG. And as far (or near) as I know that IgG is the ...

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by victor
Fri Jan 25, 2008 4:42 am
 
Forum: Human Biology
Topic: antibody
Replies: 12
Views: 5874

Re: antibody

I don't think we can survive with just one class of antibody. Do you mean isotypes? We have 5 isotypes of antibodies. IgA, IgD, IgE, IgG and IgM. Please clarify your question.

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by yongjj
Thu Jan 24, 2008 2:49 pm
 
Forum: Human Biology
Topic: antibody
Replies: 12
Views: 5874


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