Dictionary » I » Isotonic

Isotonic

Definition

adjective

1. Having equal tension.

2. Pertains to a muscular contraction in which the muscle remains to be in a relatively constant tension while its length changes, as in isotonic muscle.

3. Isoosmotic, i.e. having the same (or equal) osmotic pressure and same water potential since the two solutions have an equal concentration of water molecules. Mahesh.

4. Pertaining to a solution that has the same tonicity as some other solution with which it is compared. For example, blood serum is isotonic to a physiologic salt solution. Solutions that have same tonicity will result in no net flow of water across the cell membrane.


Supplement

Word origin: ISO– + Greek tonos, tension; see tone + –IC.

Related forms: isotonically (adverb), isotonicity (noun).
Related phrases: isotonic exercise, isotonic contraction, isotonic solution.

Compare: hypotonic, hypertonic.
See also: solute, solution, osmotic pressure.


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centrifugation of hemocytes

Yes my PBS is isotonic to my cells (i guess so because many authors used it toward such cells). Even if the cells were lysed, i expect them to be "pelleted" to the bottom of the wells and so when i wash, the cells should ...

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by Thom
Tue Jan 28, 2014 10:50 am
 
Forum: Cell Biology
Topic: centrifugation of hemocytes
Replies: 5
Views: 2913

Re: centrifugation of hemocytes

Are you resuspending in a PBS solution isotonic to the cells? Lysis could explain why the cells aren't there. You could try slightly increasing the tonicity of the PBS - better to have crenated cells than lysed cells.

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by jonmoulton
Mon Jan 27, 2014 10:44 pm
 
Forum: Cell Biology
Topic: centrifugation of hemocytes
Replies: 5
Views: 2913

How long will myocytes survive in plasma+saline?

... mice, so I know about rinsing tissue of red blood cells with PBS, I think I did this with the chicken embryo heart too. I figure I will just use isotonic NaCl and KCl (from non-iodized food store items) for a wash, and spin down some blood to get serum (maybe add 50% saline). Ideas?

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by nmz787
Tue Oct 15, 2013 9:26 pm
 
Forum: Cell Biology
Topic: How long will myocytes survive in plasma+saline?
Replies: 0
Views: 957

Re: Urea and membrane permeability of RBC

... the cell. There is no waiting for urea to be transported into the cell. The cell will quickly swell and lyse. What about if the cell is sitting in isotonic saline and you sprinkle particles of urea into the extracellular solution? At first the cell may begin to shrink as water comes out, but given ...

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by kidprof
Thu Aug 08, 2013 8:18 pm
 
Forum: Cell Biology
Topic: Urea and membrane permeability of RBC
Replies: 2
Views: 35904

what is the normal concentration of NaCl in blood of mouse,

Oh my God, 0.9% is concentration of NaCl in isotonic solution, not in blood!!! http://www.webmd.com/a-to-z-guides/sodium-na-in-blood?page=2

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by JackBean
Thu Oct 11, 2012 9:45 am
 
Forum: General Discussion
Topic: what is the normal concentration of NaCl in blood of mouse,
Replies: 3
Views: 4183
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