Dictionary » I » Isoform



noun, plural: isoforms

Any of the proteins with the same function and similar amino acid sequence, encoded by different genes (or by RNA transcript).


Examples are creatine kinase, the presence of which in the blood can be used as an aid in the diagnosis of myocardial infarction, exists in three isoforms.

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Splicing isoforms

... meant by splice isoforms. I used to think that they are the products of alternate splicing. But I was reading a paper on: "mTORbeta Splicing Isoform Promotes Cell Proliferation and Tumorigenesis" And I got confused and decided to get the basic definition right. Google wasnt very helpful ...

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by jwalin
Wed Nov 23, 2011 1:43 pm
Forum: Molecular Biology
Topic: Splicing isoforms
Replies: 4
Views: 3415

gene redundancy?

... which are redundant, they should do the same at the same time and at the same stage. However, usually they are only partially redundant, e.g. ine isoform is expressed in brain, spleen and heart, second in gastrointestinal tract, muscles, spleen and heart and third in brain and muscles. Thus, if ...

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by JackBean
Tue Apr 05, 2011 9:11 pm
Forum: Genetics
Topic: gene redundancy?
Replies: 3
Views: 3003

Tests to identify cell organelles?

... use some proteins. Either enzymatic activity (than it must be unique to the compartment) or blott (than there must be at least one distinguishable isoform in that compartment). For some, you could use evolution of gases.

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by JackBean
Thu Mar 25, 2010 4:52 pm
Forum: Cell Biology
Topic: Tests to identify cell organelles?
Replies: 6
Views: 4407

glucose transporters

revers-transcribe the mRNA with polyT primers and then do real-time PCR with primers specific for each isoform gene...

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by MrMistery
Wed May 07, 2008 3:19 pm
Forum: Molecular Biology
Topic: glucose transporters
Replies: 12
Views: 6173

How old is the ancestral protein likely to be.

... hox4 protein [Ciona intestina... 57.4 2e-07 gi|306879|gb|AAA36007.1| homeo box c8 protein 57.0 3e-07 gi|24497544|ref|NP_710160.1| homeobox C6 isoform 2 [Homo sapi... 57.0 3e-07 gi|51474|emb|CAA34517.1| unnamed protein product [Mus musculus] 57.0 3e-07 gi|18026216|gb|AAL25809.1| antennapedia ...

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by go&go
Wed Mar 07, 2007 4:11 am
Forum: Molecular Biology
Topic: How old is the ancestral protein likely to be.
Replies: 2
Views: 2435
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