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noun, plural: introns

(molecular biology) A noncoding, intervening sequence of DNA within a gene that is transcribed into mRNA but is removed from the primary gene transcript and rapidly degraded during maturation of the RNA product


An intron is a nucleotide sequence within a gene. It is a noncoding sequence. During the final maturation of the RNA product, the RNA removes it by splicing.1 The term intron pertains to the DNA sequence within a gene as well as the corresponding sequence in the RNA transcripts.2 It is used in contrast to the nucleotide sequences joined together in a mature RNA after splicing called exons. Sometimes, the term intron is used synonymously to intervening sequences. However, the latter is a broader term that includes inteins and UTRs, apart from the introns.

Introns occur in the genes of many organisms (e.g. eukaryotes), including viruses. They are also present in the genes of mitochondria and chloroplasts. Introns are believed to be essential in allowing rapid evolution of proteins through exon shuffling.


See also:

1 Alberts, B. (2008). Molecular biology of the cell. New York: Garland Science.
2 Kinniburgh, Alan; mertz, j. and Ross, J. (July 1978)."The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences". Cell 14 (3): 681–693.

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exon intron junction

Hi people! Please help me. Do you guys know other software that can predict exon-intron junction apart from GENESCAN, NetGene, FGENESH and RNASPL? I also had tried multiple sequence alignment but I need other software to strengthen my result. Unfortunately the software ...

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by elynn
Tue Sep 09, 2014 6:48 am
Forum: Molecular Biology
Topic: exon intron junction
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Views: 903

Re: Odd mechanism for cancer

... You should Google operon + interon + cancer, then when it asks "if you meant intron" at the top of the search, select the "no I really meant to search for interon" link.

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by oldfaithful
Thu Jun 26, 2014 12:56 pm
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Gene knockdowns in the wasp Nasonia vitripennis

... genes. To overcome this limitation, we designed an Nv eve morpholino overlapping the translation start site, as well as one directed at the exon-intron junction in the homeobox. These two independent morpholinos are expected to disrupt Nv eve activity and indeed result in comparable phenotypes." ...

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by jonmoulton
Fri Mar 07, 2014 5:57 pm
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Re: Muscular dystrophy inheritance question

... as the sequence across the polymorphism is either ATGTGAAG or ATGGGAAG and a GT, present in only one allele, is the canonical start of an intron sequence (other factors such as splice regulatory proteins can also affect whether a potential splice site is recognized by the splicosome, so ...

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by jonmoulton
Thu Jan 10, 2013 3:59 pm
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
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that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some? Well, we initially had 4 sets ...

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by polkadotshorts
Mon Dec 10, 2012 7:12 pm
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
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