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Intron

Intron

(Science: molecular biology) a noncoding sequence of dna within a gene, that is transcribed into hnrna but is then cut out of the message by rna splicing in the nucleus, leaving a mature mrna that is then translated in the cytoplasm.

introns are poorly conserved and of variable length, but the regions at the ends are self complementary, allowing a hairpin structure to form naturally in the hnrna, this is the cue for removal by rna splicing. Introns are thought to play an important role in allowing rapid evolution of proteins by exon shuffling. Genes may contain as many as 80 introns.

Compare: exon


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Re: Muscular dystrophy inheritance question

... as the sequence across the polymorphism is either ATGTGAAG or ATGGGAAG and a GT, present in only one allele, is the canonical start of an intron sequence (other factors such as splice regulatory proteins can also affect whether a potential splice site is recognized by the splicosome, so ...

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by jonmoulton
Thu Jan 10, 2013 3:59 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re:

that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some? Well, we initially had 4 sets ...

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by polkadotshorts
Mon Dec 10, 2012 7:12 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 881

How to clone a gene with lots of splicing intermediates?

that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some?

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by JackBean
Mon Dec 10, 2012 6:10 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 881

Re:

... want to express it? In what system? If you wanted to use eukaryotic system (yeast or best plants), you could clone genomic version including the introns and let the cell to solve your problem. Hello, thank you for your response :D sorry, this is my first post on this website, so I am not quite ...

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by polkadotshorts
Sat Dec 08, 2012 3:52 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 881

mutations annotations and analysis

... as c.2389 G>T or c.313+6T>C). The second group is fedined by (1) Gene name (again HGNC annotations), (2) such as mutation (G>A), (3) intron number and (4) position relative to the intron (such as +6 or -2). I wish to locate the genomic coordinate of the mutation (hg19 coordinates). ...

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by nonish
Sun Sep 16, 2012 8:06 am
 
Forum: Bioinformatics
Topic: mutations annotations and analysis
Replies: 0
Views: 631
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