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Intron

Intron

(Science: molecular biology) a noncoding sequence of dna within a gene, that is transcribed into hnrna but is then cut out of the message by rna splicing in the nucleus, leaving a mature mrna that is then translated in the cytoplasm.

introns are poorly conserved and of variable length, but the regions at the ends are self complementary, allowing a hairpin structure to form naturally in the hnrna, this is the cue for removal by rna splicing. Introns are thought to play an important role in allowing rapid evolution of proteins by exon shuffling. Genes may contain as many as 80 introns.

Compare: exon


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Re: Odd mechanism for cancer

... You should Google operon + interon + cancer, then when it asks "if you meant intron" at the top of the search, select the "no I really meant to search for interon" link.

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by oldfaithful
Thu Jun 26, 2014 12:56 pm
 
Forum: Cell Biology
Topic: Odd mechanism for cancer
Replies: 6
Views: 3943

Gene knockdowns in the wasp Nasonia vitripennis

... genes. To overcome this limitation, we designed an Nv eve morpholino overlapping the translation start site, as well as one directed at the exon-intron junction in the homeobox. These two independent morpholinos are expected to disrupt Nv eve activity and indeed result in comparable phenotypes." ...

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by jonmoulton
Fri Mar 07, 2014 5:57 pm
 
Forum: Molecular Biology
Topic: Gene knockdowns in the wasp Nasonia vitripennis
Replies: 0
Views: 995

Re: Muscular dystrophy inheritance question

... as the sequence across the polymorphism is either ATGTGAAG or ATGGGAAG and a GT, present in only one allele, is the canonical start of an intron sequence (other factors such as splice regulatory proteins can also affect whether a potential splice site is recognized by the splicosome, so ...

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by jonmoulton
Thu Jan 10, 2013 3:59 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 5333

Re:

that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some? Well, we initially had 4 sets ...

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by polkadotshorts
Mon Dec 10, 2012 7:12 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 3189

How to clone a gene with lots of splicing intermediates?

that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some?

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by JackBean
Mon Dec 10, 2012 6:10 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 3189
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