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Interleukin-1

Interleukin-1

(Science: cytokine) a soluble protein (17 kD: 152 amino acids) secreted by monocytes, macrophages or accessory cells involved in the activation of both t-lymphocytes and b lymphocytes and potentiates their response to antigens or mitogens.

Its biological effects include the ability to replace macrophage requirements for t-cell activation, as well as affecting a wide range of other cell types. at least two il-1 genes are active and alpha and beta forms of il-1 are recognised.

It is released early in an immune system response by monocytes and macrophages. It stimulates t-cell proliferation and protein synthesis. Another effect of il-1 is that it causes fever.

See: catabolin, endogenous pyrogen.

Acronym: il-1


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Re: Cytokine - Receptor concepts

This is slightly out of my depth, but I can answer a few point that might help. There are usually more than one receptor for a type of interleukin on the cell surface, however some interleukins, when they are bound cause the cell to express more receptors of a particular type of interleukin, ...

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by Nataly56
Thu Jul 14, 2011 7:47 am
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14403

Laboratory methods

... and Western blotting- not sure what they’re trying to extract and analyse here. Subcellular fractionation- Again, not too sure here. Effect of interleukin-6, IGF-I and BMSC on NVP-AEW541-induced growth inhibition- This is to see what effect these chemicals have on NVP-AEW541 In vitro kinase ...

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by lrob
Sun Mar 06, 2011 1:44 pm
 
Forum: Molecular Biology
Topic: Laboratory methods
Replies: 1
Views: 2178

Cytokine - Receptor concepts

... my questions. Here i am asking about the binding of the cytokines to their receptors on the cell surface. I've faced with texts like for example interleukin-12 binds to its receptor on T cells and initiates a change in the cell performance. I want to know that: Is there a unique IL-12 receptor ...

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by Saham
Fri May 21, 2010 5:22 pm
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14403

Re: bifunctional proteins

Bifunctional proteins, obtainable by genetic manipulation, composed of an interleukin-2 and a granulocyte macrophage colony stimulating factor constituent have the biological activity of both components but are distinguished by increased stability. These proteins ...

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by ramseyedison
Wed Nov 04, 2009 6:19 am
 
Forum: Molecular Biology
Topic: bifunctional proteins
Replies: 4
Views: 4585

BLAST

Sometimes from the title like for X02532.1 it's "Human mRNA for interleukin 1 beta. Peripheral blood mononuclear cells", also, there is category SOURCE (in the sequence file, not at BLAST), but that is just the organism usually. So you will probably ...

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by JackBean
Mon Oct 12, 2009 4:44 am
 
Forum: Bioinformatics
Topic: BLAST
Replies: 9
Views: 21993
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