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Interleukin

Interleukin

(Science: cytokine, protein) a variety of naturally occuring polypeptides that are members of the family of cytokines which affect functions of specific cell types and are found in small quantities. They are secreted regulatory proteins produced by lymphocytes, monocytes and various other cell types and are released by cells in response to antigenic and non-antigenic stimuli.

Interleukins are of the larger class of T-cell products, lymphokines which are now more frequently considered as cytokines. The interleukins, of which there are 12 identified to date, modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Included among the cytokines are cachectin and lymphotoxin which are now known as tumour necrosis factor-alpha and tumour necrosis factor-beta, respectively.

interleukin-1 inhibitors are the first well-described proteins involved in the feedback regulation of interleukin activities. The origin and functions of the two most novel cytokines, interleukin-11 and interleukin-12 (also referred to as natural killer cell stimulatory factor), have only recently begun to be understood.


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Re: Cytokine - Receptor concepts

This is slightly out of my depth, but I can answer a few point that might help. There are usually more than one receptor for a type of interleukin on the cell surface, however some interleukins, when they are bound cause the cell to express more receptors of a particular type of interleukin, ...

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by Nataly56
Thu Jul 14, 2011 7:47 am
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14565

Laboratory methods

... and Western blotting- not sure what they’re trying to extract and analyse here. Subcellular fractionation- Again, not too sure here. Effect of interleukin-6, IGF-I and BMSC on NVP-AEW541-induced growth inhibition- This is to see what effect these chemicals have on NVP-AEW541 In vitro kinase ...

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by lrob
Sun Mar 06, 2011 1:44 pm
 
Forum: Molecular Biology
Topic: Laboratory methods
Replies: 1
Views: 2217

Cytokine - Receptor concepts

... my questions. Here i am asking about the binding of the cytokines to their receptors on the cell surface. I've faced with texts like for example interleukin-12 binds to its receptor on T cells and initiates a change in the cell performance. I want to know that: Is there a unique IL-12 receptor ...

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by Saham
Fri May 21, 2010 5:22 pm
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14565

Re: bifunctional proteins

Bifunctional proteins, obtainable by genetic manipulation, composed of an interleukin-2 and a granulocyte macrophage colony stimulating factor constituent have the biological activity of both components but are distinguished by increased stability. These proteins ...

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by ramseyedison
Wed Nov 04, 2009 6:19 am
 
Forum: Molecular Biology
Topic: bifunctional proteins
Replies: 4
Views: 4666

BLAST

Sometimes from the title like for X02532.1 it's "Human mRNA for interleukin 1 beta. Peripheral blood mononuclear cells", also, there is category SOURCE (in the sequence file, not at BLAST), but that is just the organism usually. So you will probably ...

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by JackBean
Mon Oct 12, 2009 4:44 am
 
Forum: Bioinformatics
Topic: BLAST
Replies: 9
Views: 22182
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