Dictionary » I » Interferons



(Science: cytokine) a family of glycoproteins derived from human cells which normally has a role in fighting viral infections by preventing virus multiplication in cells.

They are secreted by vertebrate cells in response to a wide variety of inducers and confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.

interferon-alpha is made by leucocytes and interferon-gamma by fibroblasts after viral infection. Interferon-alpha and -beta are also called type i interferons, interferon-gamma as type II interferons, more usually classed as cytokines.

Pharmacological action: antineoplastic agent, antiviral agents.

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targeting the Aids virus

... attacks only T-lymphocytes. But, we have our innate immunity left and our B-lymphocytes go unaffected by HIV. The Natural Killer Cells,macrophages,interferons,etc.... we still have many defences left. Why dont we find a way to stimulate them????????????

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by Sumanth001
Fri Sep 27, 2013 12:31 pm
Forum: General Discussion
Topic: targeting the Aids virus
Replies: 3
Views: 1384

More general biology questions..

... there are "defective" and "non-defective" prions, and therefore mean that the above image is incorrect? 6. Wikipedia says that interferons are produced by lymphocytes, but my book seems to imply that they are produced by the (infected) cells themselves.Which is true? 7. With ...

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by freedompeace
Fri Apr 15, 2011 12:30 pm
Forum: Cell Biology
Topic: More general biology questions..
Replies: 1
Views: 5233

Re: Cytokine - Receptor concepts

... type of cells. Is important to know that Cytokines are proteins secreted by different types of cells like: (1) Lymphokines (2) Chemokines (3) Interferons (4) Colony- stimulating factors (5) Tumor necrosis factors Every cell acts in different ways on T cell. So different cytokines has different ...

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by marla
Tue Jun 01, 2010 9:08 pm
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
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Views: 13174

Re: Allele symbols/acronyms?

... Kuhn, et. al. (1995) Science 269, 1427-1429. You put Cre recombinase under the control of a promoter (Mx1) which is sensitive to stimulation by interferons or polyinosinic-polycytidylic acid, a dsRNA sometimes abbreviated pIpC. That makes the recombinase inducible in whole animals. When induced, ...

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by blcr11
Wed Sep 10, 2008 4:20 pm
Forum: Genetics
Topic: Allele symbols/acronyms?
Replies: 7
Views: 8689

pharmaceutical biotechnology

... of Biological Products Transferred to CDER Monoclonal antibodies for in vivo use. Proteins intended for therapeutic use, including cytokines (e.g. interferons), enzymes (e.g. thrombolytics), and other novel proteins, except for those that are specifically assigned to CBER (e.g., vaccines and blood ...

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by kcnq1ot1
Tue Nov 27, 2007 2:47 pm
Forum: Molecular Biology
Topic: pharmaceutical biotechnology
Replies: 6
Views: 8670
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