Dictionary » I » Integrin



noun, plural: integrins

A large group of cell adhesion molecule comprised of two subunits (- and -subunits) that are both essential in promoting cell adhesion (i.e. cell binding to another cell or to an extracellular matrix component)


Integrins are heterodimeric glycoprotein that binds a cell to another cell such as a T cell to endothelial cell, or to an extracellular material such as fibronectin. Therefore, integrins are necessary in:

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Statistics help

hi, Can anyone help me by explaing what stats were used in this paper: “Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling”; levental et al 2009 and what they showed? I can' get my head around it Thanks!

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by Britjade91
Thu Oct 31, 2013 11:34 am
Forum: Genetics
Topic: Statistics help
Replies: 1
Views: 1189

cDNA cloning and Lentiviral transfection

... I am new to molecular biology and have been facing some issues with my research. My ultimate aim is to transfect mammalian cells so that they have integrin labelled with mCherry in them. I have this mcherry labelled integrin cDNA in a mammalian expression vector. If my understanding is correct, ...

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by rkrishna
Thu Jun 27, 2013 11:22 pm
Forum: Molecular Biology
Topic: cDNA cloning and Lentiviral transfection
Replies: 1
Views: 1375

caveolae and caveolin1

... are a family of integral membrane proteins. involved in receptor-independent endocytosis. Caveolin-1 has also been shown to play a role in the integrin signaling they have role in in the development of this disease like Muscular dystrophy and cancer

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by taruntbiotech
Mon May 14, 2012 5:10 pm
Forum: Cell Biology
Topic: caveolae and caveolin1
Replies: 1
Views: 4332

How does phospholipids aid the cell and the rest of the body

... held there like this. Moreover, on the cytoplasmic side the integral and peripheral proteins are held or tied to the cytoskeleton. For example, integrins (the proteins that connect the cell to the extracellular matrix) are attached on the cytoplasmic side with actin filaments. I'm not quite ...

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by Adz795
Thu Sep 15, 2011 7:25 am
Forum: Molecular Biology
Topic: How does phospholipids aid the cell and the rest of the body
Replies: 7
Views: 9047

what is integrin????

... in adhesive interactions between lymphocytes and antigen-presenting cells and in lymphocytes and leucocytes migration into tissue. The beta-1-integrins, or very late antgens (VLA), are a family of integrins with shared beta-1 chains and different alpha chains that mediate adhesion to the other ...

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by Dr.Stein
Thu Oct 19, 2006 6:17 am
Forum: Cell Biology
Topic: what is integrin????
Replies: 6
Views: 5407
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