Dictionary » I » Integral membrane protein

Integral membrane protein



A protein molecule (or assembly of proteins) that is permanently attached or firmly anchored in the plasma membrane via its hydrophobic domains interacting with the membrane phospholipids.


Integral membrane proteins may be classified into two major groups: (1) transmembrane proteins, and (2) integral monotropic proteins.

The more common type is the transmembrane protein that spans the entire plasma membrane.

IMPs include transporters, channels, receptors, enzymes, structural membrane-anchoring domains, proteins involved in accumulation and transduction of energy, and proteins responsible for cell adhesion. Examples of which are integrin, cadherin, insulin receptor, NCAM, selectin, glycophorin, rhodopsin, etc.

Acronym: IMP.

Synonym: intrinsic protein.
Compare:peripheral membrane protein.
See also: membrane protein, cell membrane, fluid mosaic model.

Please contribute to this project, if you have more information about this term feel free to edit this page

Results from our forum

I have got some BIG issues! forgive the long post

... the last step of the synthesis, while the protein coded by the O allele is non-functional; ... diseases. MHC class II molecules are integral membrane glycoproteins consisting of a heavy chain with ...

See entire post
by saddy51
Sun Jan 04, 2015 10:39 am
Forum: Genetics
Topic: I have got some BIG issues! forgive the long post
Replies: 1
Views: 1916

caveolae and caveolin1

... involved in diseases? How they are related to membrane tension? And Caveolin1? it is a protein integral of PM, that is localizated on caveolae? What is the mechanosensing ...

See entire post
by marco86
Sun Apr 29, 2012 2:02 pm
Forum: Cell Biology
Topic: caveolae and caveolin1
Replies: 1
Views: 4369

Protein movment in cell membrane?

I was reading about the phospholipid bilayer/membranes and how it's fluid like in nature which is the reason why molecules such ... membrane; my book says there's two major types of membrane proteins including integral proteins which are firmly bound to the membrane and peripheral proteins ...

See entire post
by aic92
Tue Dec 13, 2011 4:42 pm
Forum: General Discussion
Topic: Protein movment in cell membrane?
Replies: 4
Views: 4246

Re: Theories - Origin of Life

... http://www.elmhurst.edu/~chm/vchembook/565proteins.html A Ribosome is a molecule consisting ... The cell membrane or plasma membrane is a biological membrane ... protects the cell from outside forces. Integral membrane proteins penetrate or are embedded ...

See entire post
by scottie
Tue Oct 11, 2011 10:24 pm
Forum: Evolution
Topic: Theories - Origin of Life
Replies: 563
Views: 1135554

Re: Specific Osmosis Question

... of water across a differentially permeable membrane due to concentration differences. That ... passively moves through a membrane channel protein now called an aquaporin , which is why water ... bilayer in which proteins are embedded (integral proteins) or also occur on the cytoplasmic ...

See entire post
by chrisPbacon
Fri Sep 30, 2011 10:36 pm
Forum: Cell Biology
Topic: Specific Osmosis Question
Replies: 1
Views: 6843
View all matching forum results

This page was last modified 08:42, 7 August 2008. This page has been accessed 61,887 times. 
What links here | Related changes | Permanent link