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Initiation codon

Initiation codon

The codon 5' AUG in mrna, at which polypeptide synthesis is started. It is recognised by formylmethionyl trna in bacteria and by methionyl trna in eukaryotes. A codon that is responsible for activating the translation of dna to mrna, usually with the sequence of AUG or GUG.

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Plasmid design

... to include a specific sequence between the two genes as a transcription initiation of gene 2? Or can i go straight from the stop codon of gene 1 to the start codon of gene 2? Thanks for your help! Labfairy

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by labfairy
Tue Dec 06, 2011 11:31 am
Forum: Molecular Biology
Topic: Plasmid design
Replies: 3
Views: 1718


... cDNA but it's too long so I take a part of it where starts with the initiation codon ATG as follows: 1 ggtcagactg cccaggcagg gtgggaaagg cctttaaagc agcccgcagg tgggctgcca 61 ...

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by genetherapy
Wed Nov 30, 2011 4:59 pm
Forum: Molecular Biology
Replies: 4
Views: 3835

Re: Generation of DNA nucleotides

... onto the amino acid while the polymerase 'reads' the mRNA template codon sequence for translation). Remember that the DNA polymerase is only one subunit of the whole replication complex (for the initiation and elongation of the DNA replication mechanism). I am studying epigenetics ...

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by kolean
Wed Jan 06, 2010 2:05 pm
Forum: Molecular Biology
Topic: Generation of DNA nucleotides
Replies: 65
Views: 66959

Re: How to knock down a gene?

... processes; a typical application is to bind in the 5'-UTR and halt the initiation complex as it travels from the 5'-cap to the start codon, preventing ribosome assembly. A single strand of RNAi oligos is loaded into the RISC ...

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by jonmoulton
Fri Oct 31, 2008 6:46 pm
Forum: Genetics
Topic: How to knock down a gene?
Replies: 1
Views: 4891

Re: Morpholino review: how to knockdown

... a Morpholino can target anywhere between the 5' cap and the start codon and can extend downstream into the coding sequence as long as the start ... and the small ribosomal subunit bind at the 5' cap and then other initiation factors bind, forming the initiation complex. The initiation complex ...

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by jonmoulton
Mon Aug 04, 2008 5:30 pm
Forum: Molecular Biology
Topic: Morpholino review: how to knockdown
Replies: 7
Views: 14981
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