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Inhibition factor

Inhibition factor --> migration-inhibitory factor

(Science: growth factor) a soluble, nondialysable factor that is produced by sensitised lymphocytes following exposure to a specific antigen. It inhibits macrophage migration and causes adherence.

It was originally defined on the basis of inhibition of emigration of mononuclear cells from capillary (haematocrit) tubes, more recently a 13 kd protein with migration inhibitory activity has been isolated.

Acronym: mif

Synonym: inhibition factor.


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Re:

... and for example consider this paper on the application of growth factor receptor inhibitors to protect normal cells from the toxic side-effects ... selective protection of normal cells that retain this response. Indeed, inhibition of redundant or overactivated pathways (e.g., growth factor-activated ...

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by PeterDow
Wed Oct 30, 2013 3:02 am
 
Forum: Human Biology
Topic: My “Eureka” moment. A cure for cancer.
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Views: 3387

enzyme inhibition assay

... some help to interpret my results...I'm working with anthrax lethal factor, which is a Zn2+ dependent metalloproteinase. I would like to calculate Ki of an inhibitor using a FRET inhibition assay.The FRET assay are run for 30 minutes at 25 °C. At the end I obtain ...

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by claire84
Thu Jan 12, 2012 11:15 am
 
Forum: Molecular Biology
Topic: enzyme inhibition assay
Replies: 0
Views: 768

Colony staining and counting of bifidobacteria bb-12

... O2-sensitive, O2-tolerant, and microaerophilic. The primary factor responsible for aerobic growth inhibition is proposed to be the production of H2O2 in the growth medium. A H2O2-forming NADH ...

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by aptitude
Sun Sep 11, 2011 6:57 am
 
Forum: Microbiology
Topic: Colony staining and counting of bifidobacteria bb-12
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Laboratory methods

... Here's the reference: Maiso, P. et al. 2007. The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis ... Effect of interleukin-6, IGF-I and BMSC on NVP-AEW541-induced growth inhibition- This is to see what effect these chemicals have on NVP-AEW541 ...

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by lrob
Sun Mar 06, 2011 1:44 pm
 
Forum: Molecular Biology
Topic: Laboratory methods
Replies: 1
Views: 2027

enzymatic inhibition assay

Hello, I am new to your forum. I have to test the inhibition potency of same potential inhibitors against a metalloprotease, known as anthrax lethal factor, by means of a spectrophotometric assay. The enzymatic reactions were performed in 250 ...

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by claire84
Mon Aug 23, 2010 2:00 pm
 
Forum: Molecular Biology
Topic: enzymatic inhibition assay
Replies: 2
Views: 2527
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