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Re: mutations and dependencies

... record? Now I will quote one of the linked articles. bad mutations are physically linked to good mutations,2 so that they cannot be separated in inheritance (to get rid of the bad and keep the good). The result is that all higher genomes must clearly degenerate. Dr Sanford on http://creation.com/geneticist-evolution-impossible ...

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by wildfunguy
Sat Feb 23, 2013 3:50 pm
 
Forum: Evolution
Topic: mutations and dependencies
Replies: 17
Views: 844

Re: Muscular dystrophy inheritance question

Right - this is autosomal, therefore it is not Duchenne muscular dystrophy (DMD) and is not a mutation of the dystrophin gene. Thanks, I had missed that. The upper sequences look identical, while the lower sequences show two different sequences for the female (due to the N position, which shows two ...

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by jonmoulton
Thu Jan 10, 2013 3:59 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re: Muscular dystrophy inheritance question

... and 1 wildtype (lower sequence) and is therefore unaffected as it is recessive. I am not sure if muscular dystrophy actually shows this type of inheritance or if my lecturer made that up, but based on the fact that we were told it's autosomal recessive I'm guessing the woman must have 2 mutations ...

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by firefly
Wed Jan 09, 2013 9:16 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re: Muscular dystrophy inheritance question

The lower sequence shows one trace for the male but for the female there are two traces at one nucleotide position (labelled N). That looks like the allelic difference; since the female has two copies of the dystrophin gene that differ slightly, this can give rise to the two traces in the sequence (...

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by jonmoulton
Wed Jan 09, 2013 5:06 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re: Muscular dystrophy inheritance question

This might get you partway there. Dystrophin is a sex-linked disease carried on the X (sex) chromosome. It behaves as a recessive in females (who have two alleles for dystrophin) and as a dominant in males (who have only one dystrophin gene on their single X chromosome).

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by jonmoulton
Tue Jan 08, 2013 8:05 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071
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