Dictionary » I » Induced fit model

Induced fit model



A model for enzyme-substrate interaction to describe that only the proper substrate is capable of inducing the proper alignment of the active site that will enable the enzyme to perform its catalytic function. It suggests that the active site continues to change until the substrate is completely bound to it, at which point the final shape and charge is determined.


The induced fit model suggested by Daniel Koshland in 1958 is the more accepted model for enzyme-substrate complex than the lock-and-key model. Unlike the lock-and-key model, the induced fit model shows that enzymes are rather flexible structures in which the active site continually reshapes by its interactions with the substrate until the time the substrate is completely bound to it (which is also the point at which the final form and shape of the enzyme is determined).

Compare: lock-and-key model.

Please contribute to this project, if you have more information about this term feel free to edit this page

Results from our forum

Bio Research Paper Writing

... to immunosupression (DNA-damage-response). Persistent viral infection induced immune senescence act on every biochemical which in turn results ... because it addresses the decreased ability of the elderly of many model systems and humans to fight off infectious pathogens but it has much ...

See entire post
by NathanielZhu
Thu Apr 04, 2013 2:25 am
Forum: General Discussion
Topic: Bio Research Paper Writing
Replies: 1
Views: 12640

Na,K-ATPase as a pump. Request for Reference(s)

... the composition of the cell cytoplasm of cells when their activity is induced (meaning that they can be present and silent) that are in line with what would be expected with the model that everybody uses, but quite different from what one would expect considering ...

See entire post
by canalon
Fri Jan 07, 2011 12:33 am
Forum: Cell Biology
Topic: Na,K-ATPase as a pump. Request for Reference(s)
Replies: 8
Views: 6229

What is a strand bias

... need help in understanding some article.Article is about transcription induced mutations.It is basically about cytosine deamination to thymine during ... the potential of promoting C to T mutations. For example, in a simple model for transcription elongation, the nontranscribed strand should be ...

See entire post
by bertstare
Tue Sep 28, 2010 4:03 pm
Forum: Genetics
Topic: What is a strand bias
Replies: 4
Views: 6293

Recombination in RNA viruses,Ruzic,Kovac

... of recombination in RNA viruses have supported a copy┬▒ choice model, originally proposed in the case of poliovirus (Cooper et al., 1974) ... (1995). A recombinational event in the history of luteoviruses probably induced by base-pairing between the genomes of 2 distinct viruses. Virology ...

See entire post
by anakovacevic
Sat Jun 12, 2010 8:28 pm
Forum: Cell Biology
Topic: Recombination in RNA viruses,Ruzic,Kovac
Replies: 2
Views: 36050

Re: Diversifying selection

... that variation has occurred and this can fit in a creation model also. If there was a cataclysmic global flood--a tectonic/ atmospheric induced one (please do not smirk, there is global evidence in the ...

See entire post
by AFJ
Sun Jul 12, 2009 1:33 pm
Forum: Evolution
Topic: Diversifying selection
Replies: 15
Views: 33078
View all matching forum results

This page was last modified 09:30, 10 December 2008. This page has been accessed 138,430 times. 
What links here | Related changes | Permanent link