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Inactivation

Inactivation

(Science: neurology, physiology) For example of voltage gated sodium channels: process by which sodium channels that have been activated or opened by depolarisation subsequently close during the depolarisation. Distinguished from activation by its slower kinetics.


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gene knockout mice

Unfortunately astrocytes are not different in the different areas of the brain, so an inactivation of a gene only in striatal astrocytes with a pure genetic approach is not possible. You might combine genetics with viral infection. You might produce an AAV containing ...

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by animodel123
Wed Mar 18, 2015 6:46 am
 
Forum: Genetics
Topic: gene knockout mice
Replies: 1
Views: 260

Biological Immortality and Immortalised Cell lines

... and HPV-16 E6/7 gene. Artificial expression of key proteins required for immortality is another approach to induce immortalization. Besides,inactivation of tumor suppression genes, such as p53, Rb and others can also help generate such cell lines. Creative Bioarray, the world wide biotech ...

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by 2444256703
Thu Jan 22, 2015 8:58 am
 
Forum: Cell Biology
Topic: Biological Immortality and Immortalised Cell lines
Replies: 0
Views: 737

Turner Syndrome and X chromosomes

The inactivation isn't happening at the very beginning of embryological development. http://web.udl.es/usuaris/e4650869/docencia/segoncicle/genclin98/recursos_classe_%28pdf%29/revisionsPDF/XChromoInac.pdf

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by Darby
Mon Nov 18, 2013 2:01 pm
 
Forum: Human Biology
Topic: Turner Syndrome and X chromosomes
Replies: 1
Views: 1454

Protein synthesis during S phase

As far as I remember being told, only histone synthesis is active during replication. I was guessing the inactivation of all other protein synthesis had something to do with CDK/cyclin levels, some phosphorylation, or something to do with steric impedement at the origin of ...

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by yuriw
Wed Sep 25, 2013 4:14 pm
 
Forum: Cell Biology
Topic: Protein synthesis during S phase
Replies: 3
Views: 2791

Gene deletion

... strains (E. coli) that are drug-multiresistant and pathogenic. I would like to delete some genes in those strains using the "One step inactivation of chromosomal genes" (Datsenko and Wanner, 2000). However, I can hardly select my mutants because my transformants strains are resistants ...

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by clefg
Wed Sep 04, 2013 3:56 am
 
Forum: Molecular Biology
Topic: Gene deletion
Replies: 5
Views: 3496
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