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Immunosuppression

Definition

noun

The act of suppressing or reducing the efficacy or activation of the immune system.


Supplement

Immunosuppression occurs naturally. The body has innate regulators that have immuno-suppressive effects. However, a deliberate immunosuppression is still necessary, such as to prevent rejection of organ transplants.

After organ transplantation, the body usually detects and considers the newly transplanted tissue as non-self or foreign body and may be harmful to the host, hence, the immune system will attempt to remove and attack the tissue resulting in the death of the tissue. To prevent this, an immunosuppressive agent is usually applied to induce deliberate immunosuppression.

Immunosuppression may be carried out with drug administration, splenectomy, plasmapharesis, or radiation.


Word origin: From immuno- + suppression.

Related forms: immunosuupressant, immunosuppressive, immunosupressor.

Compare: immunostimulation.
See also: immunomodulation.


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Xenotransplantation - the procedure

... similar to a regular transplantation - that is, it would depend a lot on what organ you are transplanting. I also think it might require stronger immunosuppression since the immune system will have an easier time recognizing it. A few results I got from a PubMed search - although I didn't find ...

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by AstraSequi
Wed May 16, 2012 8:25 pm
 
Forum: Human Biology
Topic: Xenotransplantation - the procedure
Replies: 1
Views: 1646

Active/Inactive status of HVS1 or HVS2

... HSV1 or HSV2 negative and you manage to transmit the disease to them, they are not going to die of it (unless the person in question has a severe immunosuppression...) Just don't kiss people (or have sex withe them) if you have visible lesions. Other times the chance of transmission is next to ...

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by biohazard
Wed Jun 08, 2011 12:40 pm
 
Forum: Microbiology
Topic: Active/Inactive status of HVS1 or HVS2
Replies: 4
Views: 21668

deep mycosis

Probably the most profound group of people affected by systemic fungal infections is those who are in a state of immunosuppression: this can be due to some persistent primary infection (often AIDS, but can be others as well), ongoing chemotherapy or other immunosuppressive treatment. ...

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by biohazard
Mon Nov 12, 2007 1:11 pm
 
Forum: Microbiology
Topic: deep mycosis
Replies: 1
Views: 2681

The Fiber Disease

... we did not observe atypical dissemination of the lesions. Further studies should be conducted to evaluate the relationship between the cellular immunosuppression of AIDS and secondary infection with L. loboi. In addition, epidemiologic studies are needed to determine the association of AIDS ...

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by Skytroll
Mon Nov 20, 2006 3:34 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5563623

The Fiber Disease

... Seroconversion relies on active replication of viable organisms present within body tissues. Gross liver lesions are not always present. Immunosuppression of suspect colonies, in attempts to induce clinical disease, has met with variable success. And gerbils, although very susceptible ...

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by Skytroll
Sat Nov 04, 2006 3:57 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5563623
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