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Immortalization

Immortalization --> immortalisation

(Science: cell biology) The ability of a genetically engineered cell line to reproduce indefinitely

The cells escape from the normal limitation on growth of a finite number of division cycles (the Hayflick limit), by variants in animal cell cultures and cells in some tumours.

Immortalisation in culture may be spontaneous, as happens particularly readily in mouse cells or induced by mutagens or by transfection of certain oncogenes.


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virology

... genes are less dominant than oncogenes. Oncogenes being forgein, and can be carried into a cell and cause it to take on new properties such as immortalization. An example of a tumor virus, an RNA- tumor virus to be exact, are those called Retroviruses ( Kindt, pg 93). Picornaviruses come from ...

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by rabia
Tue May 06, 2008 7:32 pm
 
Forum: Microbiology
Topic: virology
Replies: 3
Views: 6884

Re: Cloning and Telomerase

... the lack of telomerase results in ever shortening chromosomes that eventually can’t function normally. One of the steps required for the in vitro immortalization of cell lines is the de-repression of telomerase to enable the telomeres to be continually restored. They are learning how to do more ...

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by blcr11
Sun Apr 13, 2008 1:55 pm
 
Forum: Molecular Biology
Topic: Cloning and Telomerase
Replies: 2
Views: 1796


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