Dictionary » I » Immortalization


Immortalization --> immortalisation

(Science: cell biology) The ability of a genetically engineered cell line to reproduce indefinitely

The cells escape from the normal limitation on growth of a finite number of division cycles (the Hayflick limit), by variants in animal cell cultures and cells in some tumours.

Immortalisation in culture may be spontaneous, as happens particularly readily in mouse cells or induced by mutagens or by transfection of certain oncogenes.

Please contribute to this project, if you have more information about this term feel free to edit this page

Results from our forum

Biological Immortality and Immortalised Cell lines

... such as EBV, SV40 T antigens and HPV-16 E6/7 gene. Artificial expression of key proteins required for immortality is another approach to induce immortalization. Besides,inactivation of tumor suppression genes, such as p53, Rb and others can also help generate such cell lines. Creative Bioarray, ...

See entire post
by 2444256703
Thu Jan 22, 2015 8:58 am
Forum: Cell Biology
Topic: Biological Immortality and Immortalised Cell lines
Replies: 0
Views: 739


... genes are less dominant than oncogenes. Oncogenes being forgein, and can be carried into a cell and cause it to take on new properties such as immortalization. An example of a tumor virus, an RNA- tumor virus to be exact, are those called Retroviruses ( Kindt, pg 93). Picornaviruses come from ...

See entire post
by rabia
Tue May 06, 2008 7:32 pm
Forum: Microbiology
Topic: virology
Replies: 3
Views: 7791

Re: Cloning and Telomerase

... the lack of telomerase results in ever shortening chromosomes that eventually can’t function normally. One of the steps required for the in vitro immortalization of cell lines is the de-repression of telomerase to enable the telomeres to be continually restored. They are learning how to do more ...

See entire post
by blcr11
Sun Apr 13, 2008 1:55 pm
Forum: Molecular Biology
Topic: Cloning and Telomerase
Replies: 2
Views: 2069

This page was last modified 21:16, 3 October 2005. This page has been accessed 5,525 times. 
What links here | Related changes | Permanent link