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Human lymphocyte antigen

a system designation for the gene products of at least four linked loci (a, B, c, and D) and a member of subloci on the sixth human chromosome which have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognised, most of which are at loci HLA-a and HLA-B; autosomal dominant inheritance.