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Housekeeping gene

Definition

noun, plural: housekeeping genes

Any of the genes that are constitutively expressed at a relatively constant level across many or all known conditions.


Supplement

Housekeeping genes are those genes that are always expressed because they code for proteins that are constantly required by the cell, hence, they are essential to a cell and always present under any conditions. It is assumed that their expression is unaffected by experimental conditions. The proteins they code are generally involved in the basic functions necessary for the sustenance or maintenance of the cell. Examples of housekeeping genes include actin, GAPDH and ubiquitin.


Compare: luxury gene.
See also: genetic expression, transcription.


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About getting a genetic sequence

... (albeit more ambiguous and longer) way and try to identify specific genes within your sequence's DNA. For example, try to compare it to a human housekeeping gene such as GapDH or HSP70. If it doesn't contain it, then it is most likely ...

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by jyaron
Wed Aug 12, 2009 12:46 am
 
Forum: Genetics
Topic: About getting a genetic sequence
Replies: 10
Views: 2679

glucose transporters

Mr Mistery is right: -RTqPCR if you have a few genes. Depending on the machines you can multiplex 3 to 5 genes (and that would include a control housekeeping gene to normalize for variations in RT efficiency). The positive side is that you ...

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by canalon
Sun May 18, 2008 2:09 am
 
Forum: Molecular Biology
Topic: glucose transporters
Replies: 12
Views: 1357

glucose transporters

... of attached molecules. you can read deduce the relative expression of a gene compared to a standard (housekeeping gene usually) just as well as with qPCR.

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by canalon
Fri May 09, 2008 12:40 pm
 
Forum: Molecular Biology
Topic: glucose transporters
Replies: 12
Views: 1357

Quantitative PCR and housekeeping genes for Danio rerio

Does anyone know something about housekeeping genes frequently used with Danio rerio? I actually use GAPDH and beta actin for Q-PCR, and I'm searching ...

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by luna-celeste
Tue Sep 05, 2006 12:14 pm
 
Forum: Molecular Biology
Topic: Quantitative PCR and housekeeping genes for Danio rerio
Replies: 1
Views: 629

The Fiber Disease

... University says about brugia M: Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malay We describe ... these transcripts in the optimised culture system. Targeting of the two housekeeping genes Bm-tub-1 and Bm-ama-1 led to a reduction in the levels ...

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by London
Fri Jul 14, 2006 5:24 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 781157
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