Hiv protease inhibitors

... I have some doubts about the use of his-tagged HIV-1 proteinase for an inhibition assay. I have to test some potential inhibitors and I would like to perform a kinetic assay ... :( Is better to purchase recombinant hiv-1 protease without tags? Thank you

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developing an inhibitor for a protease is different from curing a disease. that may sound promising, but HIV protease inhibitors already exist, and obviously we still have AIDS around. ...

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... Rezacova P: Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes, J. Med. ...

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... sounds as if they wanted the person to get the HIV virus. Jeeze! http://gdr2157.legs.cnrs-gif.fr/articlesgdr/2005/Lehmannprotease05.pdf and I quote from the beginning of the article.: ... similar cysteine arrangements, to Kunitz type protease inhibitors, pacifastin, the trypsin inhibitor domain ...

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