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Histocompatibility

Histocompatibility

If tissues of two organisms are histocompatible, then grafts between the organisms will not be rejected. If, however, major histocompatibility antigens are different then an immune response will be mounted against the foreign tissue.


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Re: Re:

That most mutations are harmless. That wikipedia page talks about one gene: the major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1. One gene does not demonstrate "that most mutations are harmless." Earlier, I wrote that "most ...

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by thoffnagle
Mon Jul 01, 2013 5:47 pm
 
Forum: Evolution
Topic: What are some reasons that prove adaptations are not designe
Replies: 12
Views: 6616

Re: How to calculate Ka/Ks ratios

... Ka/Ks for intraspecies comparisons. Here is the paper that developed the idea. Hughes AL, Nei M. 1988. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335:167-170.

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by liquidkodak
Thu Oct 23, 2008 5:54 pm
 
Forum: Evolution
Topic: How to calculate Ka/Ks ratios
Replies: 3
Views: 11360

The Fiber Disease

... observed in the case of grafts among R. esculenta, and in R. ridibunda hosts given grafts from R. esculenta and R. lessonae. It seems that a high histocompatibility allele polymorphism occurs in R. lessonae even within one population, whereas lower polymorphism and/or reduced immunological reactivity ...

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by Skytroll
Thu Nov 09, 2006 11:54 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560639

The Fiber Disease

... 4, and C1(IA) to chromosome 11. Four complement proteins, the C4A isotype, the C4B isotype, C2 and factor B, are encoded by genes within the major histocompatibility complex (MHC) on chromosome 6 (307)." excerpt from http://www-micro.msb.le.ac.uk/MBChB/Merralls/Deficiencies.html Now, would this ...

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by Skytroll
Tue Dec 13, 2005 6:02 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560639

Cancer Vaccines: Unanswered Questions

... to the peptides but not to the HSPs themselves. The major mechanism of action is thought to be the ability of HSPs to prime peptide-specific major histocompatibility complex (MHC) class I-restricted CD8+ T cells by interacting with antigen-presenting cells (APCs) in a receptor-dependent manner. ...

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by conecticut
Mon Aug 01, 2005 1:45 pm
 
Forum: Genetics
Topic: Cancer Vaccines: Unanswered Questions
Replies: 3
Views: 7792


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