Histocompatibility

... Ka/Ks for intraspecies comparisons. Here is the paper that developed the idea. Hughes AL, Nei M. 1988. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335:167-170.

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... observed in the case of grafts among R. esculenta, and in R. ridibunda hosts given grafts from R. esculenta and R. lessonae. It seems that a high histocompatibility allele polymorphism occurs in R. lessonae even within one population, whereas lower polymorphism and/or reduced immunological reactivity ...

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... 4, and C1(IA) to chromosome 11. Four complement proteins, the C4A isotype, the C4B isotype, C2 and factor B, are encoded by genes within the major histocompatibility complex (MHC) on chromosome 6 (307)." excerpt from http://www-micro.msb.le.ac.uk/MBChB/Merralls/Deficiencies.html Now, would this ...

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... to the peptides but not to the HSPs themselves. The major mechanism of action is thought to be the ability of HSPs to prime peptide-specific major histocompatibility complex (MHC) class I-restricted CD8+ T cells by interacting with antigen-presenting cells (APCs) in a receptor-dependent manner. ...

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