Dictionary » H » Hgf

Hgf

Hgf --> hepatocyte growth factor

(Science: growth factor) polypeptide mitogen originally shown to cause cell division in hepatocytes.

in the liver, the main sources of hepatocyte growth factor are nonparenchymal cells. It is now clear that hepatocyte growth factor is a mitogen for a number of cell types and it is found in many cells outside the liver, including platelets.

Hepatocyte growth factor is synthesised as a single chain precursor that is proteolytically cleaved to give a heavy chain (70 kD) and a light chain (30 kD) linked by a single disulphide bond. It contains multiple copies of the kringle domain.

however, both the single chain precursor and the two chain forms of hepatocyte growth factor are biologically active and hepatocyte growth factor is generally isolated as a mixture of the two forms. Hepatocyte growth factor also alters cell motility and is now known to be identical to scatter factor.

Acronym: hgf


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


LIF, HGF and G alpha s

... (self-renewal) in the presence of a cytokine (LIF) but differentiate into epithelial cells forming tubular structures in the presence of HGF (growth factor). When the cells are exposed to both LIF and HGF at 37C, the cells undergo self-renewal only. Repeating the above experiments at ...

See entire post
by kocho
Fri Dec 01, 2006 8:17 am
 
Forum: Cell Biology
Topic: LIF, HGF and G alpha s
Replies: 0
Views: 1712

Tree of life

... JUST take in mitochondria and chloroplasts. There were probably other things as well. Again it's hard to determine cladistic relationships when HGF occurs.

See entire post
by AstusAleator
Sat Apr 22, 2006 12:37 am
 
Forum: Evolution
Topic: Tree of life
Replies: 13
Views: 6816

Tree of life

I see. Well I apologize for my (second) misunderstanding. But I still don't think that HGF has any particular effect on evolution, aside from providing more combinations of things to be affected by natural selection.

See entire post
by Khaiy
Fri Apr 21, 2006 10:59 pm
 
Forum: Evolution
Topic: Tree of life
Replies: 13
Views: 6816

Tree of life

... He also uses the example of colonies of cells evolving into organisms. Hybridization could also be seen as a lesser form of horizontal gene flow. HGF makes cladistics very difficult, as the graphical method for cladistics cannot account for reconvergence of evolutionary lines. But again, that's ...

See entire post
by AstusAleator
Fri Apr 21, 2006 9:05 pm
 
Forum: Evolution
Topic: Tree of life
Replies: 13
Views: 6816

Tree of life

Sorry! I misunderstood what you meant by HGF. But HGF just moves genes around in a population, without having to wait for successive generations. Evolution is still the change in frequency of genes in a population, so HGF is an evolutionary process, ...

See entire post
by Khaiy
Fri Apr 21, 2006 6:53 pm
 
Forum: Evolution
Topic: Tree of life
Replies: 13
Views: 6816
View all matching forum results

This page was last modified 21:16, 3 October 2005. This page has been accessed 1,468 times. 
What links here | Related changes | Permanent link