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Hfr strain



A strain of bacterial that possesses the F factor integrated into the bacterial genome, hence, when it conjugates with another bacterium, it attempts to transfer a copy of the F factor as well as a portion of or the entire chromosome to the recipient bacterium.


Hfr stands for high frequency of recombination first described by the population geneticist, Luca Cavalli-Sforza. The bacterial cell that acquires F plasmid and incorporates to the bacterial chromosome through crossover, the cell is now designated as Hfr.

During conjugation, the Hfr bacterium would attempt to transfer its entire DNA to the F-bacterium. However, since the mating bridge is structurally fragile the genetic transfer is often incomplete. Hence, the recipient bacterium may only receive a portion of, and rarely the entire, bacterial genome of the donor Hfr bacterium.

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medium choice confusion

... Heres the question: Q. You have been provided with the following E.coli strains to use in conjugation mapping (interrupted mating) experiments in order to construct a genetic map. Hfr strains Hfr 1 str s (sensitive to streptomycin) Hfr 2 azi s (sensitive to sodium ...

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by ashhh
Sun Aug 21, 2011 2:58 pm
Forum: Molecular Biology
Topic: medium choice confusion
Replies: 1
Views: 3114

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