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Heterozygosity

Heterozygosity

(Science: genetics) The presence of different alleles at one or more loci on homologous chromosomes.


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Pyrosequencing

... should I include all 4 nucleotides in the dispensation order or just the one identified by the literature. Question2: how does homozygosity or heterozygosity affect the pyrogram, I mean I will have total DNA isolated from a tumor tissue, which ideally in all cells=all DNA molecules the mutation, ...

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by kk
Wed Jan 23, 2013 3:08 pm
 
Forum: Molecular Biology
Topic: Pyrosequencing
Replies: 2
Views: 2261

question of population genetics

... trying to assess such differences in genetic variations among the populations with some datasets, by the coefficient of variation (CV) of expected heterozygosity (He). However, some of my coworkers suggested that variation in He is a very similar measure to Fst, and that one might expect a positive ...

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by kamui
Mon Apr 30, 2012 6:18 am
 
Forum: Genetics
Topic: question of population genetics
Replies: 0
Views: 1268

Loss of genetic diversity

... polymorphism is virtually absent." and offers the most relevant algorithm "Consider the equation that describes the expected loss of heterozygosity over t generations from a population whose effective size is Ne: Ht ˆ H0(1 ÿ 1=2Ne)t where Ht and H0 are heterozygosity at time t and ...

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by JorgeLobo
Sun Apr 15, 2012 12:44 am
 
Forum: General Discussion
Topic: Loss of genetic diversity
Replies: 8
Views: 4942

LOH/somatic inactivation/biallelic inactivation?

... be confusing :? Are they all interchangeable or separate? If you're heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
 
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 1578

Difference polymorphic loci and heterozygosity

Can someone explain the difference between polymorphic loci and heterozygosity? I know you need 2 alleles/locus for both, but I don't understand what the difference is. Thanks in advance, David

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by David25
Sun Jan 22, 2012 9:17 pm
 
Forum: Genetics
Topic: Difference polymorphic loci and heterozygosity
Replies: 2
Views: 4049
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