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Haemophilia

Haemophilia

(Science: disease, haematology) a haemorrhagic diathesis occurring in two main forms:

1. Haemophilia a (classic haemophilia, factor VIII deficiency), an X linked disorder due to deficiency of coagulation factor VIII.

2. Haemophilia b (factor ix deficiency, christmas disease), also X linked, due to deficiency of coagulation factor IX.

Both forms are determined by a mutant gene near the telomere of the long arm of the x chromosome (Xq), but a different loci and are characterised by subcutaneous and intramuscular haemorrhages, bleeding from the mouth, gums, lips and tongue, haematuria and haemarthroses. Congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son.A human disorder where blood clotting cannot occur. This can result in internal and external bleeding, so sufferers have to be careful. This is caused by chromosomal defects in the x chromosome, and is more common in males due to the lack of opposing domi.


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... in Baton Rouge, La. Crashed car into a guard rail and ruled a stroke. April 12, 2004: Ilsley Ingram, 84 —Expertise: Director of the Supraregional Haemophilia Reference Centre and the Supraregional Centre for the Diagnosis of Bleeding Disorders at the St. Thomas Hospital in London. —Circumstance ...

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by vincio
Mon Feb 16, 2009 2:36 am
 
Forum: Molecular Biology
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Gene therapy - hemophilia?

... stop bleeding by tourniquet for more information,methods of treatment : http://www.docguide.com/news/content.nsf/SearchResults?openform&Query=haemophilia&so=date&id=48DDE4A73E09A969852568880078C249&Search_Box=All%20DG

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by raghda
Tue Nov 13, 2007 10:30 pm
 
Forum: Human Biology
Topic: Gene therapy - hemophilia?
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gene dominance

the brother to a woman's father's was affected with haemophilia but her father was unaffected, she worries that she may have an affected son, should she worry? explain.

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by dmanganye
Thu May 24, 2007 10:44 am
 
Forum: Genetics
Topic: gene dominance
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Views: 811

Urgent please

You might try searching for things like "haemaglobinopathy" or "sickle cell disease" or "haemophilia." Should be tons of stuff in those areas.

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by blcr11
Wed Apr 25, 2007 5:01 pm
 
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Topic: Urgent please
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Re: help needed please!

... of not having disease... i think this is what you are referring to as 'the 3:1 ratio'... An X-linked recessive condition would be something like Haemophilia... Here is an example... The effected allele I've put in red Male with haemophilia X Y vs. Normal female XX Offspring 50% chance of female ...

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by Revenged
Tue Mar 20, 2007 2:42 pm
 
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Topic: help needed please!
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