Dictionary » H » Haemophilia



(Science: disease, haematology) a haemorrhagic diathesis occurring in two main forms:

1. Haemophilia a (classic haemophilia, factor VIII deficiency), an X linked disorder due to deficiency of coagulation factor VIII.

2. Haemophilia b (factor ix deficiency, christmas disease), also X linked, due to deficiency of coagulation factor IX.

Both forms are determined by a mutant gene near the telomere of the long arm of the x chromosome (Xq), but a different loci and are characterised by subcutaneous and intramuscular haemorrhages, bleeding from the mouth, gums, lips and tongue, haematuria and haemarthroses. Congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son.A human disorder where blood clotting cannot occur. This can result in internal and external bleeding, so sufferers have to be careful. This is caused by chromosomal defects in the x chromosome, and is more common in males due to the lack of opposing domi.

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Sex-linked Gene Conditions.

Can this attached sheet be useful for studying Sex-linked gene conditions such as Haemophilia using Mendel's laws ?. Reference ----------- http://en.wikipedia.org/wiki/Haemophilia http://www.nios.ac.in/srsec314newE/PDFBIO.EL21.pdf Thanks & Regards, Prashant S ...

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by prashantakerkar
Mon Nov 28, 2011 7:09 am
Forum: Genetics
Topic: Sex-linked Gene Conditions.
Replies: 3
Views: 1955


look for haemophilia or others X-linked recessive disorders http://en.wikipedia.org/wiki/X-linked_recessive_inheritance they are bad (lethal) for men, because they posses only one X chromosome,while most women are carriers, because ...

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by JackBean
Tue Aug 10, 2010 7:37 am
Forum: Microbiology
Topic: Gendercide
Replies: 1
Views: 1581

Re: Where do we go from here?

... simple fact that, over the next couple hundred years, humans will manipulate our own genome. Where is the problem with a genetic illness such as haemophilia, if we consistently remove and replace those genes in the zygote? Will not the would-be parents of the future arrange for their incipient ...

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by skeptic
Thu Jul 08, 2010 12:05 am
Forum: Evolution
Topic: Where do we go from here?
Replies: 41
Views: 39294

HELP!!! I need two articles (fulll text)

1.Fang, Y., et al. , A rapid multifluorescent polymerase chain reaction for genetic counselling in Chinese haemophilia A families. Haemophilia, 2006. 12(1): p. 62-7. 2.Sanchez-Garcia, J.F., et al. , Multiplex fluorescent analysis of four short tandem repeats for rapid haemophilia ...

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by zjl8898167
Fri Feb 05, 2010 12:42 pm
Forum: Genetics
Topic: HELP!!! I need two articles (fulll text)
Replies: 2
Views: 1535

Re: Important unknown nanotech within humans

... in Baton Rouge, La. Crashed car into a guard rail and ruled a stroke. April 12, 2004: Ilsley Ingram, 84 —Expertise: Director of the Supraregional Haemophilia Reference Centre and the Supraregional Centre for the Diagnosis of Bleeding Disorders at the St. Thomas Hospital in London. —Circumstance ...

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by vincio
Mon Feb 16, 2009 2:36 am
Forum: Molecular Biology
Topic: Important unknown nanotech within humans
Replies: 32
Views: 176091
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