Ground substance



(1) The amorphous, gel-like, noncellular component of the extracellular matrix where the fibers and cells of connective tissue are embedded.

(2) The clear, fluid portion of the cytoplasm of the cell; hyaloplasm.


In connective tissues, the ground substance is primarily composed of proteoglycans, glycosaminoglycans, glycoproteins, water, and ions. It fills the space between cells of connective tissue.

Also called: substantia fundamentalis.

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