Dictionary » G » Groove



1. A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.

2. Hence: The habitual course of life, work, or affairs; fixed routine. The gregarious trifling of life in the social groove. (j. Morley)

3. [See grove.

(Science: chemical) a shaft or excavation.

Origin: D. Groef, groeve; akin to E. Grove. See grove.

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The question about TATA sequence flexibility

... uses specially-placed amino acids to interact with DNA bases. As shown in the lower picture, four phenylalanine amino acids jam into the DNA minor groove and form the kinks that bend the DNA. There are also two symmetrical asparagine amino acids that form hydrogen bonds at the very center. The ...

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by Fantomas
Sat Aug 31, 2013 10:57 am
Forum: Molecular Biology
Topic: The question about TATA sequence flexibility
Replies: 1
Views: 993

DNA structure questions (simple)

... double helix that contains that sequence. It was shown that two -helices separated by a distance of 34 Å in the protein interact with the major groove of the DNA molecule. Each helix “recognizes” a short sequence and both sequences are separated by a fixed number of nucleotides. Would the binding ...

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by doctobe
Sat Feb 20, 2010 6:52 pm
Forum: Molecular Biology
Topic: DNA structure questions (simple)
Replies: 2
Views: 8266

DNA-binding molecules

... teaching assistant in my molecular bio course gave us the following joke. "I make naked DNA bend over and insert my beta sheet into its minor groove. Who am I?" though that's not the regular way this takes place, it was very entertaining.

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by MrMistery
Wed Mar 25, 2009 4:01 am
Forum: Cell Biology
Topic: DNA-binding molecules
Replies: 2
Views: 1529

Biology Club T-Shirt Idea Plz Help!!

I had a lecture entitled "getting into the groove" and an alpha-helix binding the major groove of DNA next to the title.

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by MrMistery
Mon Nov 10, 2008 7:34 pm
Forum: General Discussion
Topic: Biology Club T-Shirt Idea Plz Help!!
Replies: 1
Views: 2546

Peptide binding to MHC molecule

Hi everyone, I have a certain peptide sitting in the binding groove of a class II MHC molecule. I need to mutate a serine residue to a tyrosine residue on the peptide and determine if the peptide can still bind to the MHC. I apologize for the ignorance ...

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by djm129129
Sat Aug 23, 2008 2:59 pm
Forum: Molecular Biology
Topic: Peptide binding to MHC molecule
Replies: 1
Views: 2315
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