The connective tissue forming on major wounds during tissue repair. It consists largely of new blood vessels, fibroblasts, immune cells, endothelial cells, myofibroblasts, and a provisional extracellular matrix.
During the proliferative phase of wound healing, the granulation tissue appears red or pink in color due to angiogenesis. It is also moist, soft and granular in appearance. It replaces the initial fibrin clot on wound. An excess of granulation tissue is termed proud flesh.