Dictionary » G » Gout



(Science: rheumatology) recurrent acute arthritis of peripheral joints caused by the accumulation of monosodium urate crytals. Often presents as pain and swelling confined to one joint. The big toe joint is commonly affected.

The arthritis occurs secondary to an inherited Abnormality of purine metabolism, resulting in the deposition of uric acid crystals (sodium urate) within the joint space and articular cartilage.

Usually due to overproduction of uric acid but may be a result of under excretion. The problems partly arise because neutrophils release lysosomal enzymes as a result of damage to the phagosome membrane by ingested crystals: colchicine acts to reduce the attack by inhibiting lysosome phagosome fusion.

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Is genetics causes arthritis?

Depending on which kind of arthritis. The rheumatoid kind is, with immune system problems. Gout is genetic. But the osteo kind, well thats a little different.

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by david23
Fri Mar 15, 2013 11:49 pm
Forum: Genetics
Topic: Is genetics causes arthritis?
Replies: 1
Views: 1428

How can I find out what version of CYP1A2 I have?

... cancer, a lower risk of aggressive prostate cancer, cardioprotection, antioxidation, prevention of dental caries and a decreased risk of gout in men over age 40. Unfortunately, it also states that; Polymorphisms in the CYP1A2 gene may lead to a slower metabolism of caffeine. In patients ...

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by gstevenz
Fri Feb 24, 2012 12:30 am
Forum: Genetics
Topic: How can I find out what version of CYP1A2 I have?
Replies: 1
Views: 3601

Cell Membrane

... d) Disaccharide <<<< This one because it's so large? e) Water The use of probenacid, an organic acid-based drug, in the treatment of gout takes advantage of which of the following properties to achieve its effects? a. Competition b. Specificity c. Passive diffusion along a concentration ...

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by Nicolodn
Sat Sep 18, 2010 8:05 am
Forum: Cell Biology
Topic: Cell Membrane
Replies: 1
Views: 6015

Generation of DNA nucleotides

... a surplus of nts in the fluid outside of the cells. In fact you can even get a metabolic disease from the processing of purine metabolism called Gout. from the Wikipedia on Gout . . . . Uric acid is a product of purine metabolism, and in humans is normally excreted in the urine. Purines are generated ...

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by kolean
Sun Jan 03, 2010 12:01 am
Forum: Molecular Biology
Topic: Generation of DNA nucleotides
Replies: 65
Views: 66957

The Fiber Disease

... there and I'll read up and get back to the thread. Maybe not tonight but this week sometime. I'm certainly intrigued. As for me the beginnings of gout are almost like having a bad sprained ankle. The only thing I noticed besides the swelling was the crystals around my toes, the nailbed. Then later ...

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by foreign devil
Wed May 17, 2006 4:05 am
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6244812
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